Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/- |
| Location | 2440217..2441443 | Replicon | chromosome |
| Accession | NC_011001 | ||
| Organism | Burkholderia cenocepacia J2315 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | B4EFY1 |
| Locus tag | QU43_RS65285 | Protein ID | WP_006483155.1 |
| Coordinates | 2440862..2441443 (+) | Length | 194 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | - |
| Locus tag | QU43_RS65280 | Protein ID | WP_006483170.1 |
| Coordinates | 2440217..2440783 (+) | Length | 189 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| QU43_RS65255 | 2435610..2436245 | + | 636 | WP_006483160.1 | cysteine hydrolase | - |
| QU43_RS65260 | 2436271..2437002 | - | 732 | WP_006483157.1 | ribonuclease T2 | - |
| QU43_RS65265 | 2437233..2437622 | + | 390 | WP_006483162.1 | OsmC family protein | - |
| QU43_RS65270 | 2437701..2438273 | - | 573 | WP_006483169.1 | hypothetical protein | - |
| QU43_RS65275 | 2438367..2439770 | - | 1404 | WP_006483168.1 | hypothetical protein | - |
| QU43_RS65280 | 2440217..2440783 | + | 567 | WP_006483170.1 | helix-turn-helix domain-containing protein | Antitoxin |
| QU43_RS65285 | 2440862..2441443 | + | 582 | WP_006483155.1 | HD domain-containing protein | Toxin |
| QU43_RS65290 | 2441499..2442227 | + | 729 | WP_006483165.1 | class I SAM-dependent methyltransferase | - |
| QU43_RS65295 | 2442499..2443692 | + | 1194 | WP_006483156.1 | efflux RND transporter periplasmic adaptor subunit | - |
| QU43_RS65300 | 2443695..2445740 | + | 2046 | WP_006483164.1 | MacB family efflux pump subunit | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 194 a.a. Molecular weight: 21324.94 Da Isoelectric Point: 4.9629
>T22960 WP_006483155.1 NC_011001:2440862-2441443 [Burkholderia cenocepacia J2315]
MNPDTIRARLDFLRDAERLKDVLRSGHTSAGRAESTAEHSWRLCLMALVFAEALPGVDTLKLLKLCVVHDLGEALHGDIP
AIEQAAHPDKSVHERDDLLTLTASLDRAARDEIVALWDEYEAAASPEARAAKALDKLETILQHNQGSNPPDFDYAFNLGY
GRRYTDAAPLFSAIREIVDVDTQRRIDAGGQRA
MNPDTIRARLDFLRDAERLKDVLRSGHTSAGRAESTAEHSWRLCLMALVFAEALPGVDTLKLLKLCVVHDLGEALHGDIP
AIEQAAHPDKSVHERDDLLTLTASLDRAARDEIVALWDEYEAAASPEARAAKALDKLETILQHNQGSNPPDFDYAFNLGY
GRRYTDAAPLFSAIREIVDVDTQRRIDAGGQRA
Download Length: 582 bp
>T22960 NC_011001:2440862-2441443 [Burkholderia cenocepacia J2315]
ATGAATCCCGATACGATCCGCGCGCGCCTCGATTTCCTGCGCGACGCCGAACGCCTGAAGGACGTGCTGCGCAGCGGCCA
CACGTCGGCCGGGCGCGCGGAAAGCACGGCCGAGCATAGCTGGCGGCTGTGCCTGATGGCGCTCGTGTTCGCCGAAGCGC
TGCCCGGCGTCGATACGCTGAAGCTGCTGAAACTGTGCGTCGTCCACGACCTCGGCGAGGCGCTGCACGGCGACATCCCC
GCGATCGAGCAGGCCGCGCACCCCGACAAGAGCGTGCACGAACGCGACGACCTGCTGACGCTGACCGCGTCGCTCGACCG
CGCGGCGCGCGACGAGATCGTCGCGCTGTGGGACGAATACGAGGCGGCCGCCTCGCCGGAAGCCCGCGCGGCGAAAGCGC
TCGACAAGCTCGAAACGATCCTGCAGCACAACCAGGGCAGCAATCCGCCCGATTTCGACTATGCGTTCAATCTCGGCTAC
GGCCGGCGCTATACCGACGCCGCGCCGCTGTTCAGCGCGATCCGCGAGATCGTCGATGTCGACACGCAGCGCAGGATCGA
CGCGGGTGGGCAGCGCGCGTAA
ATGAATCCCGATACGATCCGCGCGCGCCTCGATTTCCTGCGCGACGCCGAACGCCTGAAGGACGTGCTGCGCAGCGGCCA
CACGTCGGCCGGGCGCGCGGAAAGCACGGCCGAGCATAGCTGGCGGCTGTGCCTGATGGCGCTCGTGTTCGCCGAAGCGC
TGCCCGGCGTCGATACGCTGAAGCTGCTGAAACTGTGCGTCGTCCACGACCTCGGCGAGGCGCTGCACGGCGACATCCCC
GCGATCGAGCAGGCCGCGCACCCCGACAAGAGCGTGCACGAACGCGACGACCTGCTGACGCTGACCGCGTCGCTCGACCG
CGCGGCGCGCGACGAGATCGTCGCGCTGTGGGACGAATACGAGGCGGCCGCCTCGCCGGAAGCCCGCGCGGCGAAAGCGC
TCGACAAGCTCGAAACGATCCTGCAGCACAACCAGGGCAGCAATCCGCCCGATTTCGACTATGCGTTCAATCTCGGCTAC
GGCCGGCGCTATACCGACGCCGCGCCGCTGTTCAGCGCGATCCGCGAGATCGTCGATGTCGACACGCAGCGCAGGATCGA
CGCGGGTGGGCAGCGCGCGTAA
Antitoxin
Download Length: 189 a.a. Molecular weight: 20583.56 Da Isoelectric Point: 10.7753
>AT22960 WP_006483170.1 NC_011001:2440217-2440783 [Burkholderia cenocepacia J2315]
MPHPPLHPSSLGPQLKRWRALHRVKQSHAAELFRVAQSTISRWEAGLQQMSPAERATAERLLAARLDSAGDHALARLIAG
STGRMHLVCDLTHRLLASSPARAAEFSRPLSTLLGASLWRYATPEIARMEAALDPLGWYDRAGPPSVEFDTGANASRVVP
IRGSLCRWTRMTLSDGSAVRLVETLDAH
MPHPPLHPSSLGPQLKRWRALHRVKQSHAAELFRVAQSTISRWEAGLQQMSPAERATAERLLAARLDSAGDHALARLIAG
STGRMHLVCDLTHRLLASSPARAAEFSRPLSTLLGASLWRYATPEIARMEAALDPLGWYDRAGPPSVEFDTGANASRVVP
IRGSLCRWTRMTLSDGSAVRLVETLDAH
Download Length: 567 bp
>AT22960 NC_011001:2440217-2440783 [Burkholderia cenocepacia J2315]
ATGCCCCACCCGCCGCTTCATCCATCCTCGCTCGGCCCGCAACTCAAGCGCTGGCGCGCGCTGCACCGCGTAAAGCAAAG
CCATGCAGCCGAACTGTTCCGCGTCGCGCAATCGACGATCTCCCGCTGGGAAGCCGGCCTTCAGCAGATGTCGCCCGCCG
AGCGCGCGACGGCCGAACGGCTGCTCGCCGCGCGCCTCGATTCCGCGGGCGACCACGCGCTCGCGCGGCTGATCGCCGGC
AGCACGGGCCGCATGCATCTCGTGTGCGACCTCACGCACCGCCTGCTGGCCAGCTCGCCGGCGCGCGCGGCCGAGTTCTC
GCGGCCGCTTTCGACGCTGCTCGGCGCGTCGCTGTGGCGCTATGCGACGCCGGAAATCGCCCGCATGGAAGCCGCGCTCG
ACCCGCTCGGCTGGTACGACCGCGCGGGACCGCCGAGCGTCGAGTTCGATACCGGCGCGAACGCGTCGCGCGTCGTGCCG
ATTCGCGGCAGCCTGTGCCGATGGACGCGGATGACGCTGTCGGACGGCTCGGCCGTGCGGCTCGTGGAAACGCTGGACGC
GCACTGA
ATGCCCCACCCGCCGCTTCATCCATCCTCGCTCGGCCCGCAACTCAAGCGCTGGCGCGCGCTGCACCGCGTAAAGCAAAG
CCATGCAGCCGAACTGTTCCGCGTCGCGCAATCGACGATCTCCCGCTGGGAAGCCGGCCTTCAGCAGATGTCGCCCGCCG
AGCGCGCGACGGCCGAACGGCTGCTCGCCGCGCGCCTCGATTCCGCGGGCGACCACGCGCTCGCGCGGCTGATCGCCGGC
AGCACGGGCCGCATGCATCTCGTGTGCGACCTCACGCACCGCCTGCTGGCCAGCTCGCCGGCGCGCGCGGCCGAGTTCTC
GCGGCCGCTTTCGACGCTGCTCGGCGCGTCGCTGTGGCGCTATGCGACGCCGGAAATCGCCCGCATGGAAGCCGCGCTCG
ACCCGCTCGGCTGGTACGACCGCGCGGGACCGCCGAGCGTCGAGTTCGATACCGGCGCGAACGCGTCGCGCGTCGTGCCG
ATTCGCGGCAGCCTGTGCCGATGGACGCGGATGACGCTGTCGGACGGCTCGGCCGTGCGGCTCGTGGAAACGCTGGACGC
GCACTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|