Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 848580..849237 Replicon chromosome
Accession NZ_CP089884
Organism Klebsiella pneumoniae strain KP102

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag LR951_RS04240 Protein ID WP_002916310.1
Coordinates 848827..849237 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag LR951_RS04235 Protein ID WP_002916312.1
Coordinates 848580..848846 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LR951_RS04210 (LR951_04210) 843736..845169 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
LR951_RS04215 (LR951_04215) 845288..846016 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
LR951_RS04220 (LR951_04220) 846066..846377 + 312 WP_023158440.1 N(4)-acetylcytidine aminohydrolase -
LR951_RS04225 (LR951_04225) 846541..847200 + 660 WP_002916317.1 hemolysin III family protein -
LR951_RS04230 (LR951_04230) 847351..848334 - 984 WP_032430613.1 tRNA-modifying protein YgfZ -
LR951_RS04235 (LR951_04235) 848580..848846 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
LR951_RS04240 (LR951_04240) 848827..849237 + 411 WP_002916310.1 protein YgfX Toxin
LR951_RS04245 (LR951_04245) 849244..849765 - 522 WP_004144730.1 flavodoxin FldB -
LR951_RS04250 (LR951_04250) 849866..850762 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
LR951_RS04255 (LR951_04255) 850785..851498 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LR951_RS04260 (LR951_04260) 851504..853237 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T229594 WP_002916310.1 NZ_CP089884:848827-849237 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T229594 NZ_CP124495:c4393473-4393300 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTTCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT229594 WP_002916312.1 NZ_CP089884:848580-848846 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT229594 NZ_CP124495:c4393797-4393501 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCCGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAGCATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References