Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 2068395..2070186 Replicon chromosome
Accession NC_011001
Organism Burkholderia cenocepacia J2315

Toxin (Protein)


Gene name doc Uniprot ID B4EMB1
Locus tag QU43_RS63645 Protein ID WP_006493862.1
Coordinates 2069290..2070186 (-) Length 299 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID B4EMB0
Locus tag QU43_RS63640 Protein ID WP_006487201.1
Coordinates 2068395..2069252 (-) Length 286 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QU43_RS63620 2063558..2065048 - 1491 WP_006487205.1 aldehyde dehydrogenase -
QU43_RS63625 2065121..2065948 - 828 WP_006487191.1 aspartate dehydrogenase -
QU43_RS63630 2065941..2067608 - 1668 WP_006487228.1 thiamine pyrophosphate-binding protein -
QU43_RS63635 2067601..2068398 - 798 WP_006487171.1 SDR family oxidoreductase -
QU43_RS63640 2068395..2069252 - 858 WP_006487201.1 IclR family transcriptional regulator Antitoxin
QU43_RS63645 2069290..2070186 - 897 WP_006493862.1 alpha/beta fold hydrolase Toxin
QU43_RS63650 2070205..2070732 - 528 WP_006489904.1 cupin domain-containing protein -
QU43_RS63655 2070767..2071537 - 771 WP_006489881.1 SDR family oxidoreductase -
QU43_RS63660 2071530..2072600 - 1071 WP_006489909.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
QU43_RS63665 2072655..2072966 - 312 WP_006489911.1 hypothetical protein -
QU43_RS63670 2072968..2073285 - 318 WP_006489883.1 non-heme iron oxygenase ferredoxin subunit -
QU43_RS63675 2073730..2074809 + 1080 WP_006489902.1 porin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(51-280)

Antitoxin

Transcription regulator IclR, C-terminal

(143-266)


Sequences

Toxin        


Download         Length: 299 a.a.        Molecular weight: 30515.70 Da        Isoelectric Point: 7.3891

>T22959 WP_006493862.1 NC_011001:c2070186-2069290 [Burkholderia cenocepacia J2315]
MSVIDKRERDRTAAFAALLGQFPEQRCAAGAAGTIGYREAGAQHAGRALPVVLLHGIGSGAASWVRQLDTLGASRRVLAW
DAPGYGVSTPVHGASPAAADYAAALNAWLEALGIERCVLVGHSLGAIIAGGLARVTPAQIAGLLLVSPAGGYGSAPAETR
EARRDARLAMLAELGPAGLAEQRSGNMLSGFANEEAKAWVRWNMARIVPAGYAQATHLLANADLAADLAGFRGRTAVAVG
ANDAITPPAACERIAAAAHVGLQVIPQAGHAGYVEAPAAYSALIDSFCRQCDTQWGLA

Download         Length: 897 bp

>T22959 NC_011001:c2070186-2069290 [Burkholderia cenocepacia J2315]
ATGAGTGTCATCGACAAACGTGAACGCGACCGCACCGCGGCGTTCGCCGCGCTGCTCGGGCAGTTTCCCGAGCAGCGTTG
CGCGGCCGGCGCGGCGGGCACGATCGGTTATCGCGAGGCCGGCGCGCAGCATGCGGGCCGCGCGCTGCCCGTCGTGCTGC
TGCACGGGATCGGCTCGGGCGCCGCGTCGTGGGTCCGCCAGCTCGACACGCTGGGCGCATCGCGGCGCGTGCTCGCGTGG
GATGCGCCCGGTTACGGCGTGTCGACGCCCGTGCACGGCGCGTCGCCGGCCGCCGCCGATTACGCGGCAGCGCTGAACGC
GTGGCTCGAGGCACTCGGCATCGAACGCTGCGTCCTGGTCGGCCATTCGCTCGGCGCGATCATCGCGGGCGGTCTCGCCC
GCGTGACGCCCGCGCAAATCGCCGGCCTGCTGCTGGTGTCGCCCGCGGGCGGCTACGGCAGCGCACCGGCCGAGACCCGC
GAAGCGCGCCGCGACGCACGGCTCGCGATGCTCGCGGAACTCGGCCCGGCCGGGCTCGCCGAGCAGCGCAGCGGCAACAT
GCTGTCCGGTTTCGCGAACGAGGAGGCAAAGGCATGGGTGCGCTGGAACATGGCGCGCATCGTGCCGGCCGGCTATGCGC
AGGCCACGCATCTGCTCGCGAACGCCGATCTCGCGGCCGATCTCGCCGGCTTCCGGGGCCGCACGGCCGTGGCCGTCGGC
GCGAACGACGCGATCACGCCACCCGCCGCGTGCGAGCGGATCGCCGCGGCCGCGCACGTCGGGCTGCAGGTGATTCCGCA
GGCAGGGCACGCCGGCTATGTGGAAGCGCCGGCCGCGTATTCCGCGCTGATCGACTCGTTCTGCCGGCAGTGCGATACGC
AGTGGGGGCTGGCATGA

Antitoxin


Download         Length: 286 a.a.        Molecular weight: 31372.81 Da        Isoelectric Point: 5.9820

>AT22959 WP_006487201.1 NC_011001:c2069252-2068395 [Burkholderia cenocepacia J2315]
MSEPLQQNESENAKAEASYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYK
LGIAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTTHIVIRDGRDVVFVAKAQSQSPVFSSIRVNVGTRLPAHATTHGH
VLMGDLSLKELHALYPEGVLNRMTSATPETVDALYEVIREDALRGYGVSNSSFERGISVVTAPVRNETQKIVACITVTVP
RPEIDAALIADGLIDKVQRAAAELSRRLNYRSDDEHTFLEALGLR

Download         Length: 858 bp

>AT22959 NC_011001:c2069252-2068395 [Burkholderia cenocepacia J2315]
ATGAGCGAACCGCTGCAACAAAACGAATCCGAAAACGCGAAGGCCGAAGCCAGCTACGTGGTGCCGGGCCTCGAACGCGG
GTTGCGGATTCTCGCCGAATTCTCGCCGCGCGAGCCCGTGCTCGGCGCGCCCGAACTGTCGAAGCGGCTCGGCATTCCGC
GCACGACGGTGTTCCGTCTGCTGCAGACGCTCGAATCGCTCGGCTTTCTCGAACGCGCGGACAAGGATCGCAACTACAAG
CTCGGCATCGCGGTGCTGCGGCTCGGCTTCGAATACCTGAGCTCGCTGGAGCTGACCGATCTCGGCCTGCCGGTGATCGA
AAGCCTGCGCGATGCGACCGGCTTCACGACGCACATCGTGATCCGCGACGGCCGCGACGTGGTGTTCGTCGCGAAGGCGC
AGAGCCAGTCGCCGGTGTTCAGTTCGATCCGCGTGAACGTCGGCACCCGGCTGCCCGCGCATGCGACGACGCACGGCCAC
GTGCTGATGGGCGACCTGTCGCTGAAGGAACTGCATGCGCTGTATCCGGAAGGCGTGCTGAACCGGATGACGAGCGCGAC
GCCGGAAACGGTCGACGCGCTGTACGAAGTGATCCGCGAGGATGCGCTGCGCGGCTACGGCGTCAGCAATTCGTCGTTCG
AGCGCGGGATCTCGGTCGTCACGGCGCCGGTGCGCAACGAGACGCAGAAGATCGTCGCTTGCATCACGGTGACGGTGCCG
CGTCCGGAGATCGACGCGGCGCTGATCGCGGACGGGCTGATCGACAAGGTGCAGCGCGCGGCGGCGGAACTGTCGCGGCG
GCTGAATTACCGCTCGGATGACGAGCACACGTTTCTCGAAGCTTTAGGACTCCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB B4EMB1

Antitoxin

Source ID Structure
AlphaFold DB B4EMB0

References