Detailed information of TA system TA229589

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 4865127..4866808
• Replicon: chromosome
• Accession: NZ_CP089882
• Organism: Klebsiella pneumoniae strain KP059

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: A0A486LFH0
• Locus tag: LVQ69_RS23890
• Protein ID: WP_023328808.1
• Coordinates: 4865127..4866044 (-)
• Length: 306 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: A0A486Q3T7
• Locus tag: LVQ69_RS23895
• Protein ID: WP_023328807.1
• Coordinates: 4866050..4866808 (-)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LVQ69_RS23870 (LVQ69_23835)	4860433..4861953	+	1521	WP_002885173.1	sugar ABC transporter ATP-binding protein	-
LVQ69_RS23875 (LVQ69_23840)	4861950..4862948	+	999	WP_002885172.1	ribose ABC transporter permease	-
LVQ69_RS23880 (LVQ69_23845)	4862979..4863920	+	942	WP_002885156.1	ABC transporter substrate-binding protein	-
LVQ69_RS23885 (LVQ69_23850)	4863995..4865002	+	1008	WP_023328809.1	carbohydrate kinase family protein	-
LVQ69_RS23890 (LVQ69_23855)	4865127..4866044	-	918	WP_023328808.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
LVQ69_RS23895 (LVQ69_23860)	4866050..4866808	-	759	WP_023328807.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
LVQ69_RS23900 (LVQ69_23865)	4866894..4867622	-	729	WP_002885152.1	response regulator transcription factor	-
LVQ69_RS23905 (LVQ69_23870)	4867895..4870042	+	2148	WP_077598921.1	formate dehydrogenase subunit alpha	-
LVQ69_RS23910 (LVQ69_23875)	4870272..4870958	+	687	WP_004151733.1	tetratricopeptide repeat protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-278)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (1-93)

Sequences

Toxin

Protein

• Length: 306 a.a.
• Molecular weight: 34660.13 Da
• Isoelectric Point: 5.4707

>T229589 WP_023328808.1 NZ_CP089882:c4866044-4865127 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLVEVLSPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Nucleotide

• Length: 918 bp

>T229589 NZ_CP124495:3610753-3610971 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGTCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCTGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28582.94 Da
• Isoelectric Point: 10.0870

>AT229589 WP_023328807.1 NZ_CP089882:c4866808-4866050 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTFSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp

>AT229589 NZ_CP124495:3610353-3610727 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Structures

Toxin

• AlphaFold DB: A0A486LFH0

Antitoxin

• AlphaFold DB: A0A486Q3T7