Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4701227..4701743 Replicon chromosome
Accession NZ_CP089882
Organism Klebsiella pneumoniae strain KP059

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag LVQ69_RS23060 Protein ID WP_002886902.1
Coordinates 4701227..4701511 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag LVQ69_RS23065 Protein ID WP_002886901.1
Coordinates 4701501..4701743 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVQ69_RS23035 (LVQ69_23000) 4696711..4696974 - 264 WP_014908078.1 PTS sugar transporter subunit IIB -
LVQ69_RS23040 (LVQ69_23005) 4697104..4697277 + 174 WP_019725541.1 hypothetical protein -
LVQ69_RS23045 (LVQ69_23010) 4697280..4698023 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
LVQ69_RS23050 (LVQ69_23015) 4698380..4700518 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
LVQ69_RS23055 (LVQ69_23020) 4700759..4701223 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
LVQ69_RS23060 (LVQ69_23025) 4701227..4701511 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LVQ69_RS23065 (LVQ69_23030) 4701501..4701743 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LVQ69_RS23070 (LVQ69_23035) 4701821..4703731 - 1911 WP_023328821.1 PRD domain-containing protein -
LVQ69_RS23075 (LVQ69_23040) 4703754..4704908 - 1155 WP_002886900.1 lactonase family protein -
LVQ69_RS23080 (LVQ69_23045) 4704975..4705715 - 741 WP_009486551.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T229588 WP_002886902.1 NZ_CP089882:c4701511-4701227 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T229588 NZ_CP124495:c3581022-3580720 [Escherichia coli]
ATGGCTCAAAAGAAAAATATAAGGAGTTTTCGTGATGCCTGGTTGGCTGATTTTTTTGTCCATTCAACGCCACATCGAAA
GATCCCTGCTGAAATCCATACCACGTTATCACGAAAGTTGGACATCATTAATGCTGCCACTTCTCATCGGGATTTACGCT
CCCCTCCGGGGAACCGATACGAAGAGTTATCCGGGAAATTACAGGAATACTCCTCCATTAGAGTGAATAAACAGTACCGA
CTGATTTTTAAATGGGTTAATGGCAAGGCCGAAGAATTGTTTTTAGACCCACACAACTACTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT229588 WP_002886901.1 NZ_CP089882:c4701743-4701501 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT229588 NZ_CP124495:c3580684-3580343 [Escherichia coli]
ATGAAACAGGCAACAAGAAAACCGACGACACCCGGAGATATTCTTCTCTATGAATATCTGGAACCGCTCGATTTGAAAAT
CAATGAGTTAGCAGAGTTGCTGCATGTTCATCGTAATAGCGTCAGTGCACTGATCAATAACAATCGTAAACTCACCACTG
AGATGGCATTCCGTCTGGCGAAAGTTTTTGATACCACAGTCGATTTTTGGCTAAACCTCCAGGCGGCAGTTGATCTTTGG
GAAGTTGAAAACAACATGCGTACCCAGGAAGAATTGGGACGGATTGAAACAGTGGCTGAATATTTGGCACGCCGTGAAGA
GCGTGCAAAAAAGGTCGCGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References