Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3980459..3981078 Replicon chromosome
Accession NZ_CP089882
Organism Klebsiella pneumoniae strain KP059

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag LVQ69_RS19680 Protein ID WP_002892050.1
Coordinates 3980860..3981078 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag LVQ69_RS19675 Protein ID WP_002892066.1
Coordinates 3980459..3980833 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVQ69_RS19665 (LVQ69_19635) 3975611..3976804 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
LVQ69_RS19670 (LVQ69_19640) 3976827..3979973 + 3147 WP_004147373.1 multidrug efflux RND transporter permease subunit AcrB -
LVQ69_RS19675 (LVQ69_19645) 3980459..3980833 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
LVQ69_RS19680 (LVQ69_19650) 3980860..3981078 + 219 WP_002892050.1 HHA domain-containing protein Toxin
LVQ69_RS19685 (LVQ69_19655) 3981237..3981803 + 567 WP_002892030.1 maltose O-acetyltransferase -
LVQ69_RS19690 (LVQ69_19660) 3981775..3981915 - 141 WP_004147370.1 hypothetical protein -
LVQ69_RS19695 (LVQ69_19665) 3981936..3982406 + 471 WP_002892026.1 YlaC family protein -
LVQ69_RS19700 (LVQ69_19670) 3982381..3983832 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
LVQ69_RS19705 (LVQ69_19675) 3983933..3984631 + 699 WP_002892021.1 GNAT family protein -
LVQ69_RS19710 (LVQ69_19680) 3984628..3984768 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
LVQ69_RS19715 (LVQ69_19685) 3984768..3985031 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T229586 WP_002892050.1 NZ_CP089882:3980860-3981078 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T229586 NZ_CP124495:2751355-2751462 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACAACCTGGCGGCACCGATCCTGGCGGGGATTATTACCGCAGTGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT229586 WP_002892066.1 NZ_CP089882:3980459-3980833 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT229586 NZ_CP124495:c2751298-2751243 [Escherichia coli]
CAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References