Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 805849..806506 Replicon chromosome
Accession NZ_CP089882
Organism Klebsiella pneumoniae strain KP059

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag LVQ69_RS04000 Protein ID WP_002916310.1
Coordinates 806096..806506 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag LVQ69_RS03995 Protein ID WP_002916312.1
Coordinates 805849..806115 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVQ69_RS03970 (LVQ69_03970) 801005..802438 - 1434 WP_023328360.1 6-phospho-beta-glucosidase BglA -
LVQ69_RS03975 (LVQ69_03975) 802557..803285 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
LVQ69_RS03980 (LVQ69_03980) 803335..803646 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
LVQ69_RS03985 (LVQ69_03985) 803810..804469 + 660 WP_002916317.1 hemolysin III family protein -
LVQ69_RS03990 (LVQ69_03990) 804620..805603 - 984 WP_004185555.1 tRNA-modifying protein YgfZ -
LVQ69_RS03995 (LVQ69_03995) 805849..806115 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
LVQ69_RS04000 (LVQ69_04000) 806096..806506 + 411 WP_002916310.1 protein YgfX Toxin
LVQ69_RS04005 (LVQ69_04005) 806513..807034 - 522 WP_004144730.1 flavodoxin FldB -
LVQ69_RS04010 (LVQ69_04010) 807135..808031 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
LVQ69_RS04015 (LVQ69_04015) 808054..808767 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LVQ69_RS04020 (LVQ69_04020) 808773..810506 + 1734 WP_023328361.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T229575 WP_002916310.1 NZ_CP089882:806096-806506 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T229575 NZ_CP124495:188541-188648 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGTTCCGGTCATTACTGGCATTCTTGCCAGTATGAT
CGTGAGCTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT229575 WP_002916312.1 NZ_CP089882:805849-806115 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT229575 NZ_CP124495:c188484-188427 [Escherichia coli]
TCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References