Detailed information of TA system TA229569

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 4742733..4744414
• Replicon: chromosome
• Accession: NZ_CP089880
• Organism: Klebsiella pneumoniae strain KP309

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: -
• Locus tag: LVQ72_RS23205
• Protein ID: WP_048255440.1
• Coordinates: 4742733..4743650 (-)
• Length: 306 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: A6TH05
• Locus tag: LVQ72_RS23210
• Protein ID: WP_004177809.1
• Coordinates: 4743656..4744414 (-)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LVQ72_RS23185 (LVQ72_23150)	4738039..4739559	+	1521	WP_004210021.1	sugar ABC transporter ATP-binding protein	-
LVQ72_RS23190 (LVQ72_23155)	4739556..4740554	+	999	WP_002885172.1	ribose ABC transporter permease	-
LVQ72_RS23195 (LVQ72_23160)	4740585..4741526	+	942	WP_032417723.1	ABC transporter substrate-binding protein	-
LVQ72_RS23200 (LVQ72_23165)	4741601..4742608	+	1008	WP_004178300.1	carbohydrate kinase family protein	-
LVQ72_RS23205 (LVQ72_23170)	4742733..4743650	-	918	WP_048255440.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
LVQ72_RS23210 (LVQ72_23175)	4743656..4744414	-	759	WP_004177809.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
LVQ72_RS23215 (LVQ72_23180)	4744500..4745228	-	729	WP_002885152.1	response regulator transcription factor	-
LVQ72_RS23220 (LVQ72_23185)	4745500..4747647	+	2148	WP_012737173.1	formate dehydrogenase H subunit alpha, selenocysteine-containing	-
LVQ72_RS23225 (LVQ72_23190)	4747877..4748563	+	687	WP_004151733.1	tetratricopeptide repeat protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (19-278)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (1-93)

Sequences

Toxin

Protein

• Length: 306 a.a.
• Molecular weight: 34678.10 Da
• Isoelectric Point: 5.2585

>T229569 WP_048255440.1 NZ_CP089880:c4743650-4742733 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLLYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLAEELSPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Nucleotide

• Length: 918 bp

>T229569 NZ_CP124492:c3966543-3966229 [Escherichia coli]
ATGCAATTTACGGTATACCGCAGTCGCGGCAGGAACGCCGCGTTTCCCTTTGTTATTGATGTTACCAGCGACATTATTGG
TGAGATTAATCGCCGTATCGTTATTCCATTAACACCTATTGAACGATTTAGCCGTATTCGCCCACCAGAACGGCTTAACC
CAATCCTTTTACTGGTAGACGGCAAAGAATATGTGCTCATGACGCATGAGACTGCAACTGTTCCAGTTAACGCGCTGGGA
ACGAAATTTTGCGATGCCAGCGCGCACCGAACGTTGATTAAAGGAGCATTAGATTTTATGCTCGACGGGATTTAA

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28548.92 Da
• Isoelectric Point: 10.0870

>AT229569 WP_004177809.1 NZ_CP089880:c4744414-4743656 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp

>AT229569 NZ_CP124492:c3966779-3966546 [Escherichia coli]
ATGACTGCAAAACGTACCACACAAAGTGTGACCGTCACCGTCGACCGTGAGTTAGTCAATCGCGCTCGTGATGCAGGCTT
AAATATGAGCGCCACCCTTACGGTTGCGCTCAATGCTGAACTTAAAAAACATGCAGCAACACGTTGGCGTGAAGAGAACG
CAGAAGCTATCGCTGCGTTAAATCAATTGGCTGATGAAACCGGATGTTTCTCTGATGAGTACCGGAGCTTCTAG

Structures

Antitoxin

• AlphaFold DB: A6TH05