Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4504099..4504779 Replicon chromosome
Accession NZ_CP089880
Organism Klebsiella pneumoniae strain KP309

Toxin (Protein)


Gene name yeeV Uniprot ID A0A483NEU6
Locus tag LVQ72_RS22045 Protein ID WP_004186789.1
Coordinates 4504099..4504419 (-) Length 107 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A483NFV3
Locus tag LVQ72_RS22050 Protein ID WP_004186786.1
Coordinates 4504456..4504779 (-) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVQ72_RS22020 (LVQ72_21990) 4499665..4500798 + 1134 WP_004186798.1 HNH endonuclease signature motif containing protein -
LVQ72_RS22025 (LVQ72_21995) 4500806..4501315 + 510 WP_004186797.1 YrhA family protein -
LVQ72_RS22030 (LVQ72_22000) 4501716..4502666 - 951 WP_004186795.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
LVQ72_RS22035 (LVQ72_22005) 4502659..4503054 - 396 WP_004186793.1 DUF6088 family protein -
LVQ72_RS22040 (LVQ72_22010) 4503152..4503985 - 834 WP_004186791.1 DUF4942 domain-containing protein -
LVQ72_RS22045 (LVQ72_22015) 4504099..4504419 - 321 WP_004186789.1 TA system toxin CbtA family protein Toxin
LVQ72_RS22050 (LVQ72_22020) 4504456..4504779 - 324 WP_004186786.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
LVQ72_RS22055 (LVQ72_22025) 4504792..4505262 - 471 WP_004186785.1 DNA repair protein RadC -
LVQ72_RS22060 (LVQ72_22030) 4505333..4506154 - 822 WP_004186782.1 DUF932 domain-containing protein -
LVQ72_RS22065 (LVQ72_22035) 4506264..4506725 - 462 WP_019704405.1 IrmA family protein -
LVQ72_RS22070 (LVQ72_22040) 4506843..4507472 - 630 WP_004186778.1 hypothetical protein -
LVQ72_RS22075 (LVQ72_22045) 4507478..4508179 - 702 WP_004186776.1 WYL domain-containing protein -
LVQ72_RS22080 (LVQ72_22050) 4508392..4509267 - 876 WP_019704406.1 GTPase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(11-105)

Antitoxin

Antitoxin CbeA

(7-106)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 11982.64 Da        Isoelectric Point: 6.3221

>T229567 WP_004186789.1 NZ_CP089880:c4504419-4504099 [Klebsiella pneumoniae]
MHISTVPAKVPVSSRLSPVQVWQQLLTYLLGHHYGLTLNDTPFHDDAAIEEHIDAGITLADAVNFLVERYELVRIDRKGF
SWQEQTPFLTATDILRARRATGLINT

Download         Length: 321 bp

>T229567 NZ_CP124492:3553806-3554024 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGTCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCTGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 12005.80 Da        Isoelectric Point: 6.4664

>AT229567 WP_004186786.1 NZ_CP089880:c4504779-4504456 [Klebsiella pneumoniae]
MSITPPHEWGLQSDITPRFGARLVQEGNRLYYLADRAGLTGSFSPMHLQKIDLAFPLFVEQLEDMLHAGELNPHQQCQVK
IQLASLTCIADTRGSCGYVYISIYPKP

Download         Length: 324 bp

>AT229567 NZ_CP124492:3553406-3553780 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A483NEU6

Antitoxin

Source ID Structure
AlphaFold DB A0A483NFV3

References