Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | sanaTA/AbiEii-DUF6088 |
| Location | 4501716..4503054 | Replicon | chromosome |
| Accession | NZ_CP089880 | ||
| Organism | Klebsiella pneumoniae strain KP309 | ||
Toxin (Protein)
| Gene name | sanaT | Uniprot ID | A0A483NH02 |
| Locus tag | LVQ72_RS22030 | Protein ID | WP_004186795.1 |
| Coordinates | 4501716..4502666 (-) | Length | 317 a.a. |
Antitoxin (Protein)
| Gene name | sanaA | Uniprot ID | A0A1W6B2R8 |
| Locus tag | LVQ72_RS22035 | Protein ID | WP_004186793.1 |
| Coordinates | 4502659..4503054 (-) | Length | 132 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LVQ72_RS22010 (LVQ72_21980) | 4497151..4498392 | - | 1242 | WP_004186803.1 | hypothetical protein | - |
| LVQ72_RS22015 (LVQ72_21985) | 4498923..4499243 | + | 321 | WP_040169909.1 | hypothetical protein | - |
| LVQ72_RS22020 (LVQ72_21990) | 4499665..4500798 | + | 1134 | WP_004186798.1 | HNH endonuclease signature motif containing protein | - |
| LVQ72_RS22025 (LVQ72_21995) | 4500806..4501315 | + | 510 | WP_004186797.1 | YrhA family protein | - |
| LVQ72_RS22030 (LVQ72_22000) | 4501716..4502666 | - | 951 | WP_004186795.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | Toxin |
| LVQ72_RS22035 (LVQ72_22005) | 4502659..4503054 | - | 396 | WP_004186793.1 | DUF6088 family protein | Antitoxin |
| LVQ72_RS22040 (LVQ72_22010) | 4503152..4503985 | - | 834 | WP_004186791.1 | DUF4942 domain-containing protein | - |
| LVQ72_RS22045 (LVQ72_22015) | 4504099..4504419 | - | 321 | WP_004186789.1 | TA system toxin CbtA family protein | - |
| LVQ72_RS22050 (LVQ72_22020) | 4504456..4504779 | - | 324 | WP_004186786.1 | type IV toxin-antitoxin system YeeU family antitoxin | - |
| LVQ72_RS22055 (LVQ72_22025) | 4504792..4505262 | - | 471 | WP_004186785.1 | DNA repair protein RadC | - |
| LVQ72_RS22060 (LVQ72_22030) | 4505333..4506154 | - | 822 | WP_004186782.1 | DUF932 domain-containing protein | - |
| LVQ72_RS22065 (LVQ72_22035) | 4506264..4506725 | - | 462 | WP_019704405.1 | IrmA family protein | - |
| LVQ72_RS22070 (LVQ72_22040) | 4506843..4507472 | - | 630 | WP_004186778.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | flank | IS/Tn | - | - | 4496474..4496731 | 257 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 317 a.a. Molecular weight: 36069.47 Da Isoelectric Point: 4.6461
>T229566 WP_004186795.1 NZ_CP089880:c4502666-4501716 [Klebsiella pneumoniae]
MDDLTKLFPDVADALGIESVAIVEKDHYIVELLRLLQPLSFDTHQLVFAGGTALSKAGISLNRMSEDVDIKLVPVTGFSL
QYSRNQRKNIRKDIIKTITETIVASGMFSMDEEYPKVTRDENRYNEIPVRYPQEYVQIPCLRPFIKLELMETDLLEAAEN
RAISSLVMDLTKKGEVVRAFPCATIGSTQAEKLISMMRRTAASMRDVERAVDESLVRHIYDNFCIVREKGAEVPVLKRFV
QECIEQDIQRYGAQYPEFCESPVEELKMGLEELASNPVYKERYLQFVTPMVFGESHVSWEEAYACFRITALDVIDA
MDDLTKLFPDVADALGIESVAIVEKDHYIVELLRLLQPLSFDTHQLVFAGGTALSKAGISLNRMSEDVDIKLVPVTGFSL
QYSRNQRKNIRKDIIKTITETIVASGMFSMDEEYPKVTRDENRYNEIPVRYPQEYVQIPCLRPFIKLELMETDLLEAAEN
RAISSLVMDLTKKGEVVRAFPCATIGSTQAEKLISMMRRTAASMRDVERAVDESLVRHIYDNFCIVREKGAEVPVLKRFV
QECIEQDIQRYGAQYPEFCESPVEELKMGLEELASNPVYKERYLQFVTPMVFGESHVSWEEAYACFRITALDVIDA
Download Length: 951 bp
>T229566 NZ_CP124492:c3524852-3524550 [Escherichia coli]
ATGGCTCAAAAGAAAAATATAAGGAGTTTTCGTGATGCCTGGTTGGCTGATTTTTTTGTCCATTCAACGCCACATCGAAA
GATCCCTGCTGAAATCCATACCACGTTATCACGAAAGTTGGACATCATTAATGCTGCCACTTCTCATCGGGATTTACGCT
CCCCTCCGGGGAACCGATACGAAGAGTTATCCGGGAAATTACAGGAATACTCCTCCATTAGAGTGAATAAACAGTACCGA
CTGATTTTTAAATGGGTTAATGGCAAGGCCGAAGAATTGTTTTTAGACCCACACAACTACTAA
ATGGCTCAAAAGAAAAATATAAGGAGTTTTCGTGATGCCTGGTTGGCTGATTTTTTTGTCCATTCAACGCCACATCGAAA
GATCCCTGCTGAAATCCATACCACGTTATCACGAAAGTTGGACATCATTAATGCTGCCACTTCTCATCGGGATTTACGCT
CCCCTCCGGGGAACCGATACGAAGAGTTATCCGGGAAATTACAGGAATACTCCTCCATTAGAGTGAATAAACAGTACCGA
CTGATTTTTAAATGGGTTAATGGCAAGGCCGAAGAATTGTTTTTAGACCCACACAACTACTAA
Antitoxin
Download Length: 132 a.a. Molecular weight: 14400.75 Da Isoelectric Point: 11.0360
>AT229566 WP_004186793.1 NZ_CP089880:c4503054-4502659 [Klebsiella pneumoniae]
MTIKARIQSRLKRSKRYVFTRDDFKDLAGYDQIGRALRELMKEGQLLKVGYGVYTKARQNAITGKLMPAAPGGSAAVMIE
ALERLKVDYRLAGATSAYNSGKSTQIPASLEIKTSPRFKRTLSVGSSKLNG
MTIKARIQSRLKRSKRYVFTRDDFKDLAGYDQIGRALRELMKEGQLLKVGYGVYTKARQNAITGKLMPAAPGGSAAVMIE
ALERLKVDYRLAGATSAYNSGKSTQIPASLEIKTSPRFKRTLSVGSSKLNG
Download Length: 396 bp
>AT229566 NZ_CP124492:c3524514-3524173 [Escherichia coli]
ATGAAACAGGCAACAAGAAAACCGACGACACCCGGAGATATTCTTCTCTATGAATATCTGGAACCGCTCGATTTGAAAAT
CAATGAGTTAGCAGAGTTGCTGCATGTTCATCGTAATAGCGTCAGTGCACTGATCAATAACAATCGTAAACTCACCACTG
AGATGGCATTCCGTCTGGCGAAAGTTTTTGATACCACAGTCGATTTTTGGCTAAACCTCCAGGCGGCAGTTGATCTTTGG
GAAGTTGAAAACAACATGCGTACCCAGGAAGAATTGGGACGGATTGAAACAGTGGCTGAATATTTGGCACGCCGTGAAGA
GCGTGCAAAAAAGGTCGCGTAG
ATGAAACAGGCAACAAGAAAACCGACGACACCCGGAGATATTCTTCTCTATGAATATCTGGAACCGCTCGATTTGAAAAT
CAATGAGTTAGCAGAGTTGCTGCATGTTCATCGTAATAGCGTCAGTGCACTGATCAATAACAATCGTAAACTCACCACTG
AGATGGCATTCCGTCTGGCGAAAGTTTTTGATACCACAGTCGATTTTTGGCTAAACCTCCAGGCGGCAGTTGATCTTTGG
GAAGTTGAAAACAACATGCGTACCCAGGAAGAATTGGGACGGATTGAAACAGTGGCTGAATATTTGGCACGCCGTGAAGA
GCGTGCAAAAAAGGTCGCGTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A483NH02 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A1W6B2R8 |