229563

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2556395..2557983 Replicon chromosome
Accession NZ_CP089880
Organism Klebsiella pneumoniae strain KP309

Toxin (Protein)


Gene name hipA Uniprot ID W8UI36
Locus tag LVQ72_RS12600 Protein ID WP_002904792.1
Coordinates 2556395..2557717 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag LVQ72_RS12605 Protein ID WP_002904790.1
Coordinates 2557717..2557983 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVQ72_RS12585 (LVQ72_12575) 2551451..2553952 + 2502 WP_024940923.1 fimbria/pilus outer membrane usher protein -
LVQ72_RS12590 (LVQ72_12580) 2553940..2554944 + 1005 WP_048254606.1 fimbrial protein -
LVQ72_RS12595 (LVQ72_12585) 2555086..2556378 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
LVQ72_RS12600 (LVQ72_12590) 2556395..2557717 - 1323 WP_002904792.1 type II toxin-antitoxin system HipA family toxin Toxin
LVQ72_RS12605 (LVQ72_12595) 2557717..2557983 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
LVQ72_RS12610 (LVQ72_12600) 2558370..2558696 - 327 WP_002904788.1 hydroxyisourate hydrolase -
LVQ72_RS12615 (LVQ72_12605) 2558693..2559193 - 501 WP_048254604.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
LVQ72_RS12620 (LVQ72_12610) 2559171..2560550 - 1380 WP_004199850.1 nucleobase:cation symporter-2 family protein -
LVQ72_RS12625 (LVQ72_12615) 2560896..2562050 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
LVQ72_RS12630 (LVQ72_12620) 2562031..2562954 - 924 WP_023287634.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49171.46 Da        Isoelectric Point: 7.5357

>T229563 WP_002904792.1 NZ_CP089880:c2557717-2556395 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

>T229563 NZ_CP124492:2126874-2126976 [Escherichia coli]
GCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT229563 WP_002904790.1 NZ_CP089880:c2557983-2557717 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp

>AT229563 NZ_CP124492:c2127014-2126746 [Escherichia coli]
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCTCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTTAAATATTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1CEC8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References