Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4711091..4711607 Replicon chromosome
Accession NZ_CP089877
Organism Klebsiella pneumoniae strain KP308

Toxin (Protein)


Gene name relE Uniprot ID A0A2A2BGN7
Locus tag LVQ70_RS23095 Protein ID WP_009486548.1
Coordinates 4711091..4711375 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag LVQ70_RS23100 Protein ID WP_002886901.1
Coordinates 4711365..4711607 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVQ70_RS23070 (LVQ70_23040) 4706508..4706771 - 264 WP_025368518.1 PTS sugar transporter subunit IIB -
LVQ70_RS23075 (LVQ70_23045) 4706901..4707074 + 174 WP_002886906.1 hypothetical protein -
LVQ70_RS23080 (LVQ70_23050) 4707077..4707820 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
LVQ70_RS23085 (LVQ70_23055) 4708177..4710315 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
LVQ70_RS23090 (LVQ70_23060) 4710623..4711087 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
LVQ70_RS23095 (LVQ70_23065) 4711091..4711375 - 285 WP_009486548.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LVQ70_RS23100 (LVQ70_23070) 4711365..4711607 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LVQ70_RS23105 (LVQ70_23075) 4711685..4713595 - 1911 WP_023288161.1 PRD domain-containing protein -
LVQ70_RS23110 (LVQ70_23080) 4713618..4714772 - 1155 WP_002886900.1 lactonase family protein -
LVQ70_RS23115 (LVQ70_23085) 4714839..4715579 - 741 WP_004186692.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.4951

>T229546 WP_009486548.1 NZ_CP089877:c4711375-4711091 [Klebsiella pneumoniae]
MTYELEFDPRARREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T229546 NZ_CP124490:3495796-3496014 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGTCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCTGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT229546 WP_002886901.1 NZ_CP089877:c4711607-4711365 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT229546 NZ_CP124490:3495396-3495770 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A2BGN7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References