Detailed information of TA system TA022954

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-RHH
• Location: 1878263..1878797
• Replicon: chromosome
• Accession: NC_011000
• Organism: Burkholderia cenocepacia J2315

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: QU43_RS45045
• Protein ID: WP_021033200.1
• Coordinates: 1878498..1878797 (+)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: QU43_RS45040
• Protein ID: WP_021033199.1
• Coordinates: 1878263..1878508 (+)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QU43_RS45025	1874972..1875811	+	840	WP_006486043.1	malleobactin biosynthesis enzyme MbaF	-
QU43_RS45030	1875811..1876827	+	1017	WP_006492710.1	acetyltransferase	-
QU43_RS45035	1876985..1878148	+	1164	WP_006486051.1	amidohydrolase	-
QU43_RS45040	1878263..1878508	+	246	WP_021033199.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
QU43_RS45045	1878498..1878797	+	300	WP_021033200.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
QU43_RS45050	1878888..1880192	-	1305	WP_006486048.1	cobyrinate a,c-diamide synthase	-
QU43_RS45055	1880195..1880797	-	603	WP_006476035.1	cob(I)yrinic acid a,c-diamide adenosyltransferase	-
QU43_RS45060	1880833..1881210	-	378	WP_006496449.1	cobalamin biosynthesis protein	-
QU43_RS45065	1881207..1881956	-	750	WP_012492610.1	uroporphyrinogen-III C-methyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-94)

Antitoxin

• Antitoxin ParD (1-78)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11720.37 Da
• Isoelectric Point: 6.9677

>T22954 WP_021033200.1 NC_011000:1878498-1878797 [Burkholderia cenocepacia J2315]
MAVKGRQLRLTPLAECDLEDIWRYTAEHWSPEQAEHYYRDLIGTMEALARGKKAGRICVVRDGYFRYPAGSHVVFYRETD
ETIDVIRVLHQRMDIERHL

Nucleotide

• Length: 300 bp

>T22954 NC_011000:1878498-1878797 [Burkholderia cenocepacia J2315]
ATGGCGGTTAAAGGCAGACAACTTCGGCTGACCCCGTTGGCTGAATGCGATCTTGAAGACATTTGGCGCTATACCGCCGA
GCATTGGTCGCCTGAGCAGGCAGAGCACTATTACCGCGATCTGATTGGCACCATGGAAGCGCTGGCGCGCGGCAAAAAAG
CGGGGCGGATTTGCGTTGTTCGCGACGGATATTTTCGCTACCCCGCTGGTTCTCACGTTGTGTTCTATCGCGAAACGGAT
GAAACCATCGACGTCATCCGTGTCCTGCATCAACGGATGGACATCGAACGACATCTGTAG

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 8708.68 Da
• Isoelectric Point: 7.3196

>AT22954 WP_021033199.1 NC_011000:1878263-1878508 [Burkholderia cenocepacia J2315]
MSRNTSVSLGDHFAEFVDAQVRSGRYGSASDVVRAGLRLLESHETQMRALQEALKAGEGSGTPKPFDSEAFLARMRATHG
G

Nucleotide

• Length: 246 bp

>AT22954 NC_011000:1878263-1878508 [Burkholderia cenocepacia J2315]
ATGTCGCGAAACACATCCGTTTCCCTTGGCGATCACTTTGCAGAATTTGTCGATGCGCAGGTGCGATCGGGACGATATGG
TTCCGCAAGTGACGTCGTGCGAGCCGGGTTGCGGCTCCTCGAATCACACGAAACGCAAATGCGTGCATTGCAGGAAGCAT
TGAAGGCGGGTGAAGGGTCGGGGACGCCCAAGCCCTTCGACAGCGAGGCCTTCCTGGCCCGCATGCGGGCCACGCATGGC
GGTTAA