Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 794726..795383 Replicon chromosome
Accession NZ_CP089877
Organism Klebsiella pneumoniae strain KP308

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag LVQ70_RS03945 Protein ID WP_002916310.1
Coordinates 794973..795383 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag LVQ70_RS03940 Protein ID WP_002916312.1
Coordinates 794726..794992 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVQ70_RS03915 (LVQ70_03915) 789934..791367 - 1434 WP_009485881.1 6-phospho-beta-glucosidase BglA -
LVQ70_RS03920 (LVQ70_03920) 791486..792214 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
LVQ70_RS03925 (LVQ70_03925) 792264..792575 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
LVQ70_RS03930 (LVQ70_03930) 792739..793398 + 660 WP_002916317.1 hemolysin III family protein -
LVQ70_RS03935 (LVQ70_03935) 793497..794480 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
LVQ70_RS03940 (LVQ70_03940) 794726..794992 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
LVQ70_RS03945 (LVQ70_03945) 794973..795383 + 411 WP_002916310.1 protein YgfX Toxin
LVQ70_RS03950 (LVQ70_03950) 795390..795911 - 522 WP_002916308.1 flavodoxin FldB -
LVQ70_RS03955 (LVQ70_03955) 796012..796908 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
LVQ70_RS03960 (LVQ70_03960) 796931..797644 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LVQ70_RS03965 (LVQ70_03965) 797650..799383 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T229534 WP_002916310.1 NZ_CP089877:794973-795383 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T229534 NZ_CP124490:188058-188165 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT229534 WP_002916312.1 NZ_CP089877:794726-794992 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT229534 NZ_CP124490:c188009-187944 [Escherichia coli]
GTCTAGATGCAAGAATGGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References