Detailed information of TA system TA229525

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 4647348..4647864
• Replicon: chromosome
• Accession: NZ_CP089874
• Organism: Klebsiella pneumoniae strain KP106

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: LVQ73_RS22755
• Protein ID: WP_040225317.1
• Coordinates: 4647348..4647632 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: R4Y888
• Locus tag: LVQ73_RS22760
• Protein ID: WP_002886901.1
• Coordinates: 4647622..4647864 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LVQ73_RS22730 (4642823)	4642823..4643086	-	264	WP_004152271.1	PTS sugar transporter subunit IIB	-
LVQ73_RS22735 (4643216)	4643216..4643389	+	174	WP_065900585.1	hypothetical protein	-
LVQ73_RS22740 (4643392)	4643392..4644135	+	744	WP_002886905.1	MurR/RpiR family transcriptional regulator	-
LVQ73_RS22745 (4644492)	4644492..4646630	+	2139	WP_049117635.1	anaerobic ribonucleoside-triphosphate reductase	-
LVQ73_RS22750 (4646880)	4646880..4647344	+	465	WP_004222151.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
LVQ73_RS22755 (4647348)	4647348..4647632	-	285	WP_040225317.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LVQ73_RS22760 (4647622)	4647622..4647864	-	243	WP_002886901.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
LVQ73_RS22765 (4647942)	4647942..4649852	-	1911	WP_101985323.1	PRD domain-containing protein	-
LVQ73_RS22770 (4649875)	4649875..4651029	-	1155	WP_023301365.1	lactonase family protein	-
LVQ73_RS22775 (4651096)	4651096..4651836	-	741	WP_004186692.1	KDGP aldolase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-83)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-80)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11172.02 Da
• Isoelectric Point: 10.3787

>T229525 WP_040225317.1 NZ_CP089874:c4647632-4647348 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNLRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Nucleotide

• Length: 285 bp

>T229525 NZ_CP124487:c3630327-3630025 [Escherichia coli]
ATGGCTCAAAAGAAAAATATAAGGAGTTTTCGTGATGCCTGGTTGGCTGATTTTTTTGTCCATTCAACGCCACATCGAAA
GATCCCTGCTGAAATCCATACCACGTTATCACGAAAGTTGGACATCATTAATGCTGCCACTTCTCATCGGGATTTACGCT
CCCCTCCGGGGAACCGATACGAAGAGTTATCCGGGAAATTACAGGAATACTCCTCCATTAGAGTGAATAAACAGTACCGA
CTGATTTTTAAATGGGTTAATGGCAAGGCCGAAGAATTGTTTTTAGACCCACACAACTACTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9045.55 Da
• Isoelectric Point: 6.3340

>AT229525 WP_002886901.1 NZ_CP089874:c4647864-4647622 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Nucleotide

• Length: 243 bp

>AT229525 NZ_CP124487:c3629989-3629648 [Escherichia coli]
ATGAAACAGGCAACAAGAAAACCGACGACACCCGGAGATATTCTTCTCTATGAATATCTGGAACCGCTCGATTTGAAAAT
CAATGAGTTAGCAGAGTTGCTGCATGTTCATCGTAATAGCGTCAGTGCACTGATCAATAACAATCGTAAACTCACCACTG
AGATGGCATTCCGTCTGGCGAAAGTTTTTGATACCACAGTCGATTTTTGGCTAAACCTCCAGGCGGCAGTTGATCTTTGG
GAAGTTGAAAACAACATGCGTACCCAGGAAGAATTGGGACGGATTGAAACAGTGGCTGAATATTTGGCACGCCGTGAAGA
GCGTGCAAAAAAGGTCGCGTAG

Structures

Antitoxin

• AlphaFold DB: A0A0H3GLP0