Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3954897..3955516 Replicon chromosome
Accession NZ_CP089874
Organism Klebsiella pneumoniae strain KP106

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag LVQ73_RS19500 Protein ID WP_002892050.1
Coordinates 3955298..3955516 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag LVQ73_RS19495 Protein ID WP_002892066.1
Coordinates 3954897..3955271 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVQ73_RS19485 (3950049) 3950049..3951242 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
LVQ73_RS19490 (3951265) 3951265..3954411 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
LVQ73_RS19495 (3954897) 3954897..3955271 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
LVQ73_RS19500 (3955298) 3955298..3955516 + 219 WP_002892050.1 HHA domain-containing protein Toxin
LVQ73_RS19505 (3955675) 3955675..3956241 + 567 WP_002892030.1 maltose O-acetyltransferase -
LVQ73_RS19510 (3956213) 3956213..3956353 - 141 WP_004147370.1 hypothetical protein -
LVQ73_RS19515 (3956374) 3956374..3956844 + 471 WP_002892026.1 YlaC family protein -
LVQ73_RS19520 (3956819) 3956819..3958270 - 1452 WP_277722088.1 PLP-dependent aminotransferase family protein -
LVQ73_RS19525 (3958371) 3958371..3959069 + 699 WP_004177238.1 GNAT family protein -
LVQ73_RS19530 (3959066) 3959066..3959206 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
LVQ73_RS19535 (3959206) 3959206..3959469 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T229523 WP_002892050.1 NZ_CP089874:3955298-3955516 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T229523 NZ_CP124487:2753406-2753513 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACAACCTGGCGGCACCGATCCTGGCGGGGATTATTACCGCAGTGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT229523 WP_002892066.1 NZ_CP089874:3954897-3955271 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT229523 NZ_CP124487:c2753349-2753294 [Escherichia coli]
CAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References