Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4720411..4720927 Replicon chromosome
Accession NZ_CP089870
Organism Klebsiella pneumoniae strain KP037

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag LVQ68_RS22930 Protein ID WP_004178374.1
Coordinates 4720411..4720695 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag LVQ68_RS22935 Protein ID WP_002886901.1
Coordinates 4720685..4720927 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVQ68_RS22905 (4715807) 4715807..4716070 - 264 WP_014908078.1 PTS sugar transporter subunit IIB -
LVQ68_RS22910 (4716200) 4716200..4716373 + 174 WP_032103426.1 hypothetical protein -
LVQ68_RS22915 (4716376) 4716376..4717119 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
LVQ68_RS22920 (4717476) 4717476..4719614 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
LVQ68_RS22925 (4719943) 4719943..4720407 + 465 WP_004222151.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
LVQ68_RS22930 (4720411) 4720411..4720695 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LVQ68_RS22935 (4720685) 4720685..4720927 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LVQ68_RS22940 (4721005) 4721005..4722915 - 1911 WP_015959311.1 PRD domain-containing protein -
LVQ68_RS22945 (4722938) 4722938..4724092 - 1155 WP_004178372.1 lactonase family protein -
LVQ68_RS22950 (4724159) 4724159..4724899 - 741 WP_015959310.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T229505 WP_004178374.1 NZ_CP089870:c4720695-4720411 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T229505 NZ_CP124483:c3978624-3978310 [Escherichia coli]
ATGCAATTTACGGTATACCGCAGTCGCGGCAGGAACGCCGCGTTTCCCTTTGTTATTGATGTTACCAGCGACATTATTGG
TGAGATTAATCGCCGTATCGTTATTCCATTAACACCTATTGAACGATTTAGCCGTATTCGCCCACCAGAACGGCTTAACC
CAATCCTTTTACTGGTAGACGGCAAAGAATATGTGCTCATGACGCATGAGACTGCAACTGTTCCAGTTAACGCGCTGGGA
ACGAAATTTTGCGATGCCAGCGCGCACCGAACGTTGATTAAAGGAGCATTAGATTTTATGCTCGACGGGATTTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT229505 WP_002886901.1 NZ_CP089870:c4720927-4720685 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT229505 NZ_CP124483:c3978860-3978627 [Escherichia coli]
ATGACTGCAAAACGTACCACACAAAGTGTGACCGTCACCGTCGACCGTGAGTTAGTCAATCGCGCTCGTGATGCAGGCTT
AAATATGAGCGCCACCCTTACGGTTGCGCTCAATGCTGAACTTAAAAAACATGCAGCAACACGTTGGCGTGAAGAGAACG
CAGAAGCTATCGCTGCGTTAAATCAATTGGCTGATGAAACCGGATGTTTCTCTGATGAGTACCGGAGCTTCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References