Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3980316..3980935 Replicon chromosome
Accession NZ_CP089870
Organism Klebsiella pneumoniae strain KP037

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag LVQ68_RS19475 Protein ID WP_002892050.1
Coordinates 3980717..3980935 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag LVQ68_RS19470 Protein ID WP_002892066.1
Coordinates 3980316..3980690 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVQ68_RS19460 (3975468) 3975468..3976661 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
LVQ68_RS19465 (3976684) 3976684..3979830 + 3147 WP_004147373.1 multidrug efflux RND transporter permease subunit AcrB -
LVQ68_RS19470 (3980316) 3980316..3980690 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
LVQ68_RS19475 (3980717) 3980717..3980935 + 219 WP_002892050.1 HHA domain-containing protein Toxin
LVQ68_RS19480 (3981094) 3981094..3981660 + 567 WP_002892030.1 maltose O-acetyltransferase -
LVQ68_RS19485 (3981632) 3981632..3981772 - 141 WP_004147370.1 hypothetical protein -
LVQ68_RS19490 (3981793) 3981793..3982263 + 471 WP_002892026.1 YlaC family protein -
LVQ68_RS19495 (3982238) 3982238..3983689 - 1452 WP_038989586.1 PLP-dependent aminotransferase family protein -
LVQ68_RS19500 (3983790) 3983790..3984488 + 699 WP_032434109.1 GNAT family protein -
LVQ68_RS19505 (3984485) 3984485..3984625 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
LVQ68_RS19510 (3984625) 3984625..3984888 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T229503 WP_002892050.1 NZ_CP089870:3980717-3980935 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T229503 NZ_CP124483:3565888-3566106 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGTCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCTGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT229503 WP_002892066.1 NZ_CP089870:3980316-3980690 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT229503 NZ_CP124483:3565488-3565862 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References