Detailed information of TA system TA229502

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2657993..2659581
• Replicon: chromosome
• Accession: NZ_CP089870
• Organism: Klebsiella pneumoniae strain KP037

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: A6T928
• Locus tag: LVQ68_RS13005
• Protein ID: WP_004176197.1
• Coordinates: 2657993..2659315 (-)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: A0A0H3GXD8
• Locus tag: LVQ68_RS13010
• Protein ID: WP_002904790.1
• Coordinates: 2659315..2659581 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LVQ68_RS12990 (2653049)	2653049..2655550	+	2502	WP_032412215.1	fimbria/pilus outer membrane usher protein	-
LVQ68_RS12995 (2655538)	2655538..2656542	+	1005	WP_032434525.1	fimbrial protein	-
LVQ68_RS13000 (2656684)	2656684..2657976	+	1293	WP_002904794.1	glycoside hydrolase family 10 protein	-
LVQ68_RS13005 (2657993)	2657993..2659315	-	1323	WP_004176197.1	type II toxin-antitoxin system HipA family toxin	Toxin
LVQ68_RS13010 (2659315)	2659315..2659581	-	267	WP_002904790.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
LVQ68_RS13015 (2659847)	2659847..2660173	-	327	WP_002904788.1	hydroxyisourate hydrolase	-
LVQ68_RS13020 (2660170)	2660170..2660670	-	501	WP_032434523.1	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	-
LVQ68_RS13025 (2660648)	2660648..2662027	-	1380	WP_004184021.1	nucleobase:cation symporter-2 family protein	-
LVQ68_RS13030 (2662373)	2662373..2663527	+	1155	WP_002904783.1	FAD-dependent urate hydroxylase HpxO	-
LVQ68_RS13035 (2663508)	2663508..2664431	-	924	WP_002904781.1	LysR family hpxDE operon transcriptional regulator HpxR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (16-65)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49111.41 Da
• Isoelectric Point: 7.5357

>T229502 WP_004176197.1 NZ_CP089870:c2659315-2657993 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Nucleotide

• Length: 1323 bp

>T229502 NZ_CP124483:c3536934-3536632 [Escherichia coli]
ATGGCTCAAAAGAAAAATATAAGGAGTTTTCGTGATGCCTGGTTGGCTGATTTTTTTGTCCATTCAACGCCACATCGAAA
GATCCCTGCTGAAATCCATACCACGTTATCACGAAAGTTGGACATCATTAATGCTGCCACTTCTCATCGGGATTTACGCT
CCCCTCCGGGGAACCGATACGAAGAGTTATCCGGGAAATTACAGGAATACTCCTCCATTAGAGTGAATAAACAGTACCGA
CTGATTTTTAAATGGGTTAATGGCAAGGCCGAAGAATTGTTTTTAGACCCACACAACTACTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9906.27 Da
• Isoelectric Point: 8.5912

>AT229502 WP_002904790.1 NZ_CP089870:c2659581-2659315 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Nucleotide

• Length: 267 bp

>AT229502 NZ_CP124483:c3536596-3536255 [Escherichia coli]
ATGAAACAGGCAACAAGAAAACCGACGACACCCGGAGATATTCTTCTCTATGAATATCTGGAACCGCTCGATTTGAAAAT
CAATGAGTTAGCAGAGTTGCTGCATGTTCATCGTAATAGCGTCAGTGCACTGATCAATAACAATCGTAAACTCACCACTG
AGATGGCATTCCGTCTGGCGAAAGTTTTTGATACCACAGTCGATTTTTGGCTAAACCTCCAGGCGGCAGTTGATCTTTGG
GAAGTTGAAAACAACATGCGTACCCAGGAAGAATTGGGACGGATTGAAACAGTGGCTGAATATTTGGCACGCCGTGAAGA
GCGTGCAAAAAAGGTCGCGTAG

Structures

Toxin

• AlphaFold DB: A6T928

Antitoxin

• AlphaFold DB: A0A0H3GXD8