Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vagCD/VapC-VagC |
| Location | 1844451..1845094 | Replicon | chromosome |
| Accession | NZ_CP089870 | ||
| Organism | Klebsiella pneumoniae strain KP037 | ||
Toxin (Protein)
| Gene name | vagD | Uniprot ID | A4GZE5 |
| Locus tag | LVQ68_RS08915 | Protein ID | WP_015874977.1 |
| Coordinates | 1844451..1844867 (-) | Length | 139 a.a. |
Antitoxin (Protein)
| Gene name | vagC | Uniprot ID | A4GZE4 |
| Locus tag | LVQ68_RS08920 | Protein ID | WP_015874976.1 |
| Coordinates | 1844864..1845094 (-) | Length | 77 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LVQ68_RS08895 (1839854) | 1839854..1840969 | - | 1116 | WP_032447702.1 | salmochelin biosynthesis C-glycosyltransferase IroB | - |
| LVQ68_RS08900 (1841142) | 1841142..1841420 | - | 279 | Protein_1739 | ISNCY family transposase | - |
| LVQ68_RS08905 (1841841) | 1841841..1844015 | + | 2175 | WP_015874979.1 | siderophore salmochelin receptor IroN | - |
| LVQ68_RS08910 (1844170) | 1844170..1844415 | - | 246 | WP_032447699.1 | hypothetical protein | - |
| LVQ68_RS08915 (1844451) | 1844451..1844867 | - | 417 | WP_015874977.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| LVQ68_RS08920 (1844864) | 1844864..1845094 | - | 231 | WP_015874976.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
| LVQ68_RS08925 (1845537) | 1845537..1845917 | + | 381 | WP_015874975.1 | YrzE family protein | - |
| LVQ68_RS08930 (1846105) | 1846105..1847075 | + | 971 | Protein_1745 | IS21-like element IS100 family transposase | - |
| LVQ68_RS08935 (1847102) | 1847102..1847828 | + | 727 | Protein_1746 | IS21-like element helper ATPase IstB | - |
| LVQ68_RS08940 (1847872) | 1847872..1847985 | - | 114 | WP_015874970.1 | Hha/YmoA family nucleoid-associated regulatory protein | - |
| LVQ68_RS08945 (1848228) | 1848228..1848437 | - | 210 | WP_032447696.1 | TraR/DksA family transcriptional regulator | - |
| LVQ68_RS08950 (1848427) | 1848427..1849008 | - | 582 | WP_000937857.1 | DUF2857 domain-containing protein | - |
| LVQ68_RS08955 (1848993) | 1848993..1849175 | - | 183 | WP_072001695.1 | hypothetical protein | - |
| LVQ68_RS08960 (1849197) | 1849197..1849382 | - | 186 | WP_000205185.1 | AlpA family transcriptional regulator | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | rmpA / iroD / iroC / iroB / iroN / fyuA / ybtE / ybtT / ybtU | 1801312..1864771 | 63459 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 139 a.a. Molecular weight: 14945.39 Da Isoelectric Point: 8.5464
>T229493 WP_015874977.1 NZ_CP089870:c1844867-1844451 [Klebsiella pneumoniae]
MKKTWMLDTNICSFIMREQPAAVLKRLEQAGLRGDRIVVSAVTYAEMRFGATGPKASPHHIQLVDAFCARLDAILPWDRA
AVDATTDIRVALRLAGTPIGPNDTAIAGHAIAAGAVLVTNNVREFARVPGLVLEDWVK
MKKTWMLDTNICSFIMREQPAAVLKRLEQAGLRGDRIVVSAVTYAEMRFGATGPKASPHHIQLVDAFCARLDAILPWDRA
AVDATTDIRVALRLAGTPIGPNDTAIAGHAIAAGAVLVTNNVREFARVPGLVLEDWVK
Download Length: 417 bp
>T229493 NZ_CP124483:699923-700237 [Escherichia coli]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCTTCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTCGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCCGTTCATCGTACTAAGGGGAAAAAATGA
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCTTCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTCGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCCGTTCATCGTACTAAGGGGAAAAAATGA
Antitoxin
Download Length: 77 a.a. Molecular weight: 8749.80 Da Isoelectric Point: 4.3533
>AT229493 WP_015874976.1 NZ_CP089870:c1845094-1844864 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRADPDFMVEREDVVSDEGRFEP
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRADPDFMVEREDVVSDEGRFEP
Download Length: 231 bp
>AT229493 NZ_CP124483:700234-700650 [Escherichia coli]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTACTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGTGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTTCCGGAAATAGGCAGTAAATCGATGGT
GTCACGCGTTTTGAGCGGGAAAAGGAAATTAACGCTGGAACACGCTAAAAAACTGGCAACGCGATTCGGTATTTCTCCCG
CCTTGTTTATTGATTAA
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTACTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGTGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTTCCGGAAATAGGCAGTAAATCGATGGT
GTCACGCGTTTTGAGCGGGAAAAGGAAATTAACGCTGGAACACGCTAAAAAACTGGCAACGCGATTCGGTATTTCTCCCG
CCTTGTTTATTGATTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|