Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 3002568..3003788 Replicon chromosome
Accession NZ_CP089849
Organism Pseudomonas aeruginosa strain PA0523

Toxin (Protein)


Gene name vapC Uniprot ID A0A0H2Z8V4
Locus tag LVE67_RS14440 Protein ID WP_003110488.1
Coordinates 3002568..3003146 (-) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LVE67_RS14445 Protein ID WP_003088112.1
Coordinates 3003234..3003788 (-) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVE67_RS14425 (LVE67_14425) 2997843..2999120 + 1278 WP_003110491.1 TolC family protein -
LVE67_RS14430 (LVE67_14430) 2999110..3001281 + 2172 WP_003110490.1 type I secretion system permease/ATPase -
LVE67_RS14435 (LVE67_14435) 3001271..3002458 + 1188 WP_003110489.1 HlyD family efflux transporter periplasmic adaptor subunit -
LVE67_RS14440 (LVE67_14440) 3002568..3003146 - 579 WP_003110488.1 HD domain-containing protein Toxin
LVE67_RS14445 (LVE67_14445) 3003234..3003788 - 555 WP_003088112.1 helix-turn-helix transcriptional regulator Antitoxin
LVE67_RS14450 (LVE67_14450) 3003946..3006141 - 2196 WP_003110487.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
LVE67_RS14455 (LVE67_14455) 3006146..3006607 - 462 WP_003102736.1 (2Fe-2S)-binding protein -
LVE67_RS14460 (LVE67_14460) 3006938..3007261 + 324 WP_003102734.1 multidrug efflux SMR transporter -
LVE67_RS14465 (LVE67_14465) 3007274..3007672 + 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
LVE67_RS14470 (LVE67_14470) 3007669..3008219 - 551 Protein_2862 XRE family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

5'-deoxynucleotidase YfbR/HDDC2

(7-188)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21913.75 Da        Isoelectric Point: 5.3655

>T229485 WP_003110488.1 NZ_CP089849:c3003146-3002568 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDTPLRDRLLALWDEYERGETAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Download         Length: 579 bp

>T229485 NZ_CP124482:c53210-53076 [Escherichia coli]
ATGACGAAATATACCCTTATCGGGTTGCTTGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACAGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTGA

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT229485 WP_003088112.1 NZ_CP089849:c3003788-3003234 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp

>AT229485 NZ_CP124482:53255-53315 [Escherichia coli]
TAAAGTGCATCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2Z8V4

Antitoxin

Source ID Structure

References