Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 549690..550225 Replicon plasmid pC
Accession NC_010997
Organism Rhizobium etli CIAT 652

Toxin (Protein)


Gene name relE Uniprot ID B3Q5V1
Locus tag RHECIAT_RS28030 Protein ID WP_012490004.1
Coordinates 549690..549965 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID F2AEZ7
Locus tag RHECIAT_RS28035 Protein ID WP_004677393.1
Coordinates 549965..550225 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RHECIAT_RS28010 544881..545807 - 927 WP_012490002.1 sugar ABC transporter permease -
RHECIAT_RS28015 545875..547095 - 1221 WP_004677398.1 sugar ABC transporter substrate-binding protein -
RHECIAT_RS28020 547145..548467 - 1323 WP_012490003.1 alpha-L-fucosidase -
RHECIAT_RS28025 548676..549683 + 1008 WP_004677397.1 LacI family transcriptional regulator -
RHECIAT_RS28030 549690..549965 - 276 WP_012490004.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
RHECIAT_RS28035 549965..550225 - 261 WP_004677393.1 ribbon-helix-helix domain-containing protein Antitoxin
RHECIAT_RS28040 550525..551253 + 729 WP_004677391.1 FadR family transcriptional regulator -
RHECIAT_RS28045 551544..552557 + 1014 WP_012490006.1 ABC transporter substrate-binding protein -
RHECIAT_RS28050 552653..553471 + 819 WP_004677388.1 ABC transporter ATP-binding protein -
RHECIAT_RS28055 553483..554364 + 882 WP_012490008.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - virD4 / gmd 1..1091523 1091523


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(6-43)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10830.44 Da        Isoelectric Point: 9.5543

>T22948 WP_012490004.1 NC_010997:c549965-549690 [Rhizobium etli CIAT 652]
MEIKWTSKAVSDIARLYDFLSPIDRRAAARTVQALAAAPARLIEQPRLGERLEEFDPQEVRRILVGRYEMRYEIQQSTIY
VLRLWHTREDR

Download         Length: 276 bp

>T22948 NC_010997:c549965-549690 [Rhizobium etli CIAT 652]
ATGGAAATCAAGTGGACGAGCAAAGCTGTCTCCGACATCGCTCGCTTATACGACTTTCTCTCCCCGATCGACCGGCGAGC
TGCGGCCCGAACCGTGCAGGCGCTGGCGGCAGCCCCCGCTCGTCTAATTGAGCAGCCACGTCTCGGCGAGCGGCTCGAAG
AGTTCGATCCTCAGGAGGTCCGCCGCATTCTCGTTGGCCGTTATGAGATGCGTTATGAAATCCAGCAGTCGACAATCTAT
GTATTGCGGCTTTGGCATACGCGCGAGGATCGGTAG

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9686.93 Da        Isoelectric Point: 4.6135

>AT22948 WP_004677393.1 NC_010997:c550225-549965 [Rhizobium etli CIAT 652]
METKVLTAHVPLPLAQKVDQLASRLERSRGWIVKQALTAWIDQEEERRRLTLEALADVDSGNVVDHQSVQAWADSLDGDE
PISLLR

Download         Length: 261 bp

>AT22948 NC_010997:c550225-549965 [Rhizobium etli CIAT 652]
ATGGAGACCAAAGTTCTCACGGCTCATGTTCCATTGCCGCTTGCGCAGAAGGTCGATCAGCTTGCATCGCGCCTTGAGCG
TTCGCGCGGCTGGATCGTCAAGCAAGCCCTGACTGCATGGATCGACCAGGAAGAGGAGCGTCGGCGTTTGACGCTTGAGG
CGTTAGCCGATGTGGATAGCGGCAATGTTGTCGATCACCAGTCTGTTCAAGCCTGGGCCGATAGTCTTGACGGTGACGAG
CCGATTTCGTTGCTCCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7X6IWB5

Antitoxin

Source ID Structure
AlphaFold DB A0A2U3CQR5

References