Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 956070..956652 Replicon chromosome
Accession NZ_CP089848
Organism Paralcaligenes sp. KSB-10

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag LSG25_RS04365 Protein ID WP_232743491.1
Coordinates 956314..956652 (+) Length 113 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag LSG25_RS04360 Protein ID WP_232743490.1
Coordinates 956070..956294 (+) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LSG25_RS04350 (LSG25_04350) 952484..953185 + 702 WP_232743488.1 epoxyqueuosine reductase QueH -
LSG25_RS04355 (LSG25_04355) 953257..955851 - 2595 WP_232743489.1 ATP-dependent chaperone ClpB -
LSG25_RS04360 (LSG25_04360) 956070..956294 + 225 WP_232743490.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
LSG25_RS04365 (LSG25_04365) 956314..956652 + 339 WP_232743491.1 endoribonuclease MazF Toxin
LSG25_RS04370 (LSG25_04370) 956996..957904 + 909 WP_232743492.1 LysR family transcriptional regulator -
LSG25_RS04375 (LSG25_04375) 958013..959338 - 1326 WP_232743493.1 isocitrate lyase -
LSG25_RS04380 (LSG25_04380) 959651..960481 + 831 WP_232743494.1 NADPH-dependent 7-cyano-7-deazaguanine reductase QueF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-109)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 113 a.a.        Molecular weight: 12259.36 Da        Isoelectric Point: 9.7631

>T229475 WP_232743491.1 NZ_CP089848:956314-956652 [Paralcaligenes sp. KSB-10]
MSKRYIPTAGDIIWLHFDVPKGSTGPGYKPAVVLSPLAYNKKTGLMICCPITPTIKGYPFEVLIDAEQRIAALSDQIKSL
DWASSKISHQGRISSSELAEIRAKLQALIFKG

Download         Length: 339 bp

>T229475 NZ_CP124481:c2569969-2568647 [Escherichia coli]
ATGCCTAAACTAGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAACGGCGCGCACACCTTTAA
GTATGCAGCTGAGTGGTTAGCCAGCCGTTATGCCAGACCGTTGTCACTTTCGCTGCCATTGCAGAGGGGGAATATCACCT
CTGATGCCGTATTTAACTTCTTCGATAACCTGTTACCCGATAGCCCGATTGTACGTGACCGGATCGTTAAACGTTATCAT
GCTAAATCCAGACAACCGTTTGATTTATTGTCAGAAATAGGGCGAGACAGCGTTGGTGCCGTGACGTTAATCCCCGAAGA
TGAAACCGTAACGTGTCCGATAATGGCATGGGAAAAGCTTACTGAAGCCAGACTTGAAGAAGTATTAACGGCTTATAAAG
CAGATATCCCGTTAGGCATGATTAGAGAAGAAAATGACTTTCGCATCTCGGTTGCTGGCGCACAGGAGAAGACTGCGCTG
CTCAGAATAGGCAATGACTGGTGCATTCCGAAGGGAATAACGCCAACGACGCACATTATCAAATTGCCGATTGGCGAAAT
CAGACAGCCCAATGCGACGCTCGATCTTAGCCAAAGCGTTGATAATGAGTATTACTGTTTGCTGCTGGCGAAAGAACTCG
GGTTGAATGTTCCGGACGCAGAAATCATTAAAGCGGGAAGGGTGCGCGCGTTAGCGGTCGAACGTTTTGACAGGCGTTGG
AATACTGAGCGAACGGTTTTACTTCGCTTGCCACAGGAGGATATGTGCCAGACATTCGGTTTACCTTCATCGGTGAAATA
TGAATCAGATGGAGGCCCCGGTATCGCGCAAATTATGGCTTTTTTGATGGGGTCCAGCGAGGCGCTGAAAGATCGCTATG
ATTTTATGAAGTTTCAGGTCTTCCAGTGGTTGATTGGCGCAACGGATGGCCATGCAAAAAACTTCTCCGTATTTATTCAG
GCTGGCGGCAGTTATCGGCTCACACCATTTTACGACATCATTTCGGCATTTCCGGTCCTTGGCGGTACGGGAATACACAT
CAGCGATCTCAAACTGGCAATGGGGCTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATTTATCCGCGACATT
TTCTGGCGACAGCAAAGGTGCTGAAATTCCCGGAAGTGCAGATGCATGAAATCCTGAGTGACTTTGCCAGAATGATTCCG
GCAGCACTGGATAACGTGAAGACTTCATTACCGACAGATTTTCCGGAGAACGTGGTGACGGCAGTTGAAACCAATGTGTT
GAGGTTGCACGATCGGTTAAGCCGAGAATACGGTATTAAGTAA

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8130.52 Da        Isoelectric Point: 7.2022

>AT229475 WP_232743490.1 NZ_CP089848:956070-956294 [Paralcaligenes sp. KSB-10]
MRGVIKKWGNSAAVRLPSSMMKTLKLDLEDVINISVEHGNIVIEPIRTEEYVLSQLLGGIKAKNIHAEIDFGAA

Download         Length: 225 bp

>AT229475 NZ_CP124481:c2570235-2569969 [Escherichia coli]
ATGATGAGCTTTCAGAAGATCTATAGCCCAACGCAATTGGCGAATGCAATGAAACTGGTTCGCCAGCAAAACGGCTGGAC
GCAGAGCGAGTTGGCGAAAAAAATCGGCATTAAGCAGGCGACAATTTCCAATTTCGAAAACAATCCTGACAATACCTCGC
TCACGACATTTTTTAAGATTTTACAGTCGCTTGAACTCTCAATGACGCTATGCGACGCGAAAAATGCCTCGCCAGAAGCA
ACAGAACAGCAAGATCTGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References