Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4289798..4290579 Replicon chromosome
Accession NZ_CP089799
Organism Salmonella enterica subsp. enterica serovar Kentucky strain ZTA19/00785

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A3G3E5T9
Locus tag LUY21_RS20825 Protein ID WP_000625911.1
Coordinates 4289798..4290289 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID V7IUD2
Locus tag LUY21_RS20830 Protein ID WP_001271379.1
Coordinates 4290286..4290579 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LUY21_RS20800 (4284934) 4284934..4287372 - 2439 WP_023224120.1 F4 (K88) fimbrial usher FaeD -
LUY21_RS20805 (4287382) 4287382..4287921 - 540 WP_000721295.1 type 1 fimbrial protein -
LUY21_RS20810 (4287956) 4287956..4288246 - 291 WP_000773469.1 PapB/FocB family fimbrial expression transcriptional regulator -
LUY21_RS20815 (4288833) 4288833..4289060 + 228 WP_001112992.1 hypothetical protein -
LUY21_RS20820 (4289335) 4289335..4289583 - 249 Protein_4072 IS481 family transposase -
LUY21_RS20825 (4289798) 4289798..4290289 - 492 WP_000625911.1 GNAT family N-acetyltransferase Toxin
LUY21_RS20830 (4290286) 4290286..4290579 - 294 WP_001271379.1 DUF1778 domain-containing protein Antitoxin
LUY21_RS20835 (4290897) 4290897..4291118 + 222 WP_052939504.1 hypothetical protein -
LUY21_RS20840 (4291384) 4291384..4292259 + 876 WP_023205266.1 AraC family transcriptional regulator -
LUY21_RS20845 (4292256) 4292256..4292543 + 288 WP_072103482.1 transcriptional regulator RtsB -
LUY21_RS20850 (4292536) 4292536..4292718 - 183 WP_072106065.1 ATP-binding cassette domain-containing protein -
LUY21_RS20855 (4292738) 4292738..4292837 + 100 Protein_4079 hypothetical protein -
LUY21_RS20860 (4292885) 4292885..4293079 + 195 WP_223163373.1 hypothetical protein -
LUY21_RS20865 (4293374) 4293374..4294279 - 906 WP_001268192.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - faeI / faeH / faeF / faeE / faeD / faeC 4276776..4292718 15942


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-144)

Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17663.44 Da        Isoelectric Point: 7.2655

>T229472 WP_000625911.1 NZ_CP089799:c4290289-4289798 [Salmonella enterica subsp. enterica serovar Kentucky]
MISSPEPLHAGHILTPFCCGVDSMDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTAPGRFRRNMPDP
IPIVVLGRLAVDKSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFEPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

>T229472 NZ_CP124481:1487615-1487917 [Escherichia coli]
ATGGCTCAAAAGAAAAATATAAGGAGTTTTCGTGATGCCTGGTTGGCTGATTTTTTTGTCCATTCAACGCCACATCGAAA
GATCCCTGCTGAAATCCATACCACGTTATCACGAAAGTTGGACATCATTAATGCTGCCACTTCTCATCGGGATTTACGCT
CCCCTCCGGGGAACCGATACGAAGAGTTATCCGGGAAATTACAGGAATACTCCTCCATTAGAGTGAATAAACAGTACCGA
CTGATTTTTAAATGGGTTAATGGCAAGGCCGAAGAATTGTTTTTAGACCCACACAACTACTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10938.54 Da        Isoelectric Point: 9.8590

>AT229472 WP_001271379.1 NZ_CP089799:c4290579-4290286 [Salmonella enterica subsp. enterica serovar Kentucky]
MSAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT229472 NZ_CP124481:1487953-1488294 [Escherichia coli]
ATGAAACAGGCAACAAGAAAACCGACGACACCCGGAGATATTCTTCTCTATGAATATCTGGAACCGCTCGATTTGAAAAT
CAATGAGTTAGCAGAGTTGCTGCATGTTCATCGTAATAGCGTCAGTGCACTGATCAATAACAATCGTAAACTCACCACTG
AGATGGCATTCCGTCTGGCGAAAGTTTTTGATACCACAGTCGATTTTTGGCTAAACCTCCAGGCGGCAGTTGATCTTTGG
GAAGTTGAAAACAACATGCGTACCCAGGAAGAATTGGGACGGATTGAAACAGTGGCTGAATATTTGGCACGCCGTGAAGA
GCGTGCAAAAAAGGTCGCGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G3E5T9

Antitoxin

Source ID Structure
AlphaFold DB V7IUD2

References