Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 4151612..4152255 Replicon chromosome
Accession NZ_CP089799
Organism Salmonella enterica subsp. enterica serovar Kentucky strain ZTA19/00785

Toxin (Protein)


Gene name vagD Uniprot ID B5F3H8
Locus tag LUY21_RS20095 Protein ID WP_000048134.1
Coordinates 4151839..4152255 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID B5F3H9
Locus tag LUY21_RS20090 Protein ID WP_001261294.1
Coordinates 4151612..4151842 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LUY21_RS20080 (4148625) 4148625..4150763 + 2139 WP_000187821.1 anaerobic ribonucleoside-triphosphate reductase -
LUY21_RS20085 (4150980) 4150980..4151444 + 465 WP_001009178.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
LUY21_RS20090 (4151612) 4151612..4151842 + 231 WP_001261294.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LUY21_RS20095 (4151839) 4151839..4152255 + 417 WP_000048134.1 type II toxin-antitoxin system VapC family toxin Toxin
LUY21_RS20100 (4152316) 4152316..4154229 - 1914 WP_001212148.1 BglG family transcription antiterminator -
LUY21_RS20105 (4154246) 4154246..4154986 - 741 WP_000779255.1 KDGP aldolase family protein -
LUY21_RS20110 (4154983) 4154983..4156101 - 1119 WP_023224150.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
LUY21_RS20115 (4156085) 4156085..4157218 - 1134 WP_023224151.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-44)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15135.50 Da        Isoelectric Point: 8.1381

>T229471 WP_000048134.1 NZ_CP089799:4151839-4152255 [Salmonella enterica subsp. enterica serovar Kentucky]
MSKTYMLDTCICSFIMREQPEAVLKRLEQAVLRRHRIVVSAITYAEMRFGCTGKKASPRHAQLVDAFCSRLDAVLAWDRA
AVDATTEIRAVLAAAGTPIGSNDAAIAGHAIASGAILVTNNVREFERVPGLQYEDWVK

Download         Length: 417 bp

>T229471 NZ_CP124481:c1458661-1458443 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGTCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCTGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8878.90 Da        Isoelectric Point: 4.6677

>AT229471 WP_001261294.1 NZ_CP089799:4151612-4151842 [Salmonella enterica subsp. enterica serovar Kentucky]
MRTVSVFKNGNNRAIRLPRDLDFDGVNELEIFREGDTIILRPARPSWGSFRHEEKASPDFLTEREDIISDEGRFEL

Download         Length: 231 bp

>AT229471 NZ_CP124481:c1459061-1458687 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2T8L749

Antitoxin

Source ID Structure
AlphaFold DB A0A3V4SIC2

References