Detailed information of TA system TA022947

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/Phd(antitoxin)
• Location: 4465312..4465859
• Replicon: chromosome
• Accession: NC_010995
• Organism: Cellvibrio japonicus Ueda107

Toxin (Protein)

• Gene name: relE
• Uniprot ID: B3PHY2
• Locus tag: CJA_RS17950
• Protein ID: WP_012489297.1
• Coordinates: 4465312..4465614 (-)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: CJA_RS17955
• Protein ID: WP_041552696.1
• Coordinates: 4465602..4465859 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CJA_RS18875	4460413..4460808	+	396	WP_012489292.1	helix-turn-helix domain-containing protein	-
CJA_RS17930	4460817..4461323	+	507	WP_012489293.1	methylated-DNA--[protein]-cysteine S-methyltransferase	-
CJA_RS17935	4461342..4463450	-	2109	WP_012489294.1	TonB-dependent receptor	-
CJA_RS17940	4463559..4463750	-	192	WP_202944247.1	DUF3185 family protein	-
CJA_RS17945	4463970..4465286	+	1317	WP_012489296.1	ATP-binding protein	-
CJA_RS17950	4465312..4465614	-	303	WP_012489297.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CJA_RS17955	4465602..4465859	-	258	WP_041552696.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
CJA_RS17960	4466002..4466235	-	234	WP_012489299.1	hypothetical protein	-
CJA_RS17965	4466410..4466634	+	225	WP_148208933.1	helix-turn-helix domain-containing protein	-
CJA_RS17970	4466798..4467067	-	270	WP_041551805.1	DUF4019 domain-containing protein	-
CJA_RS17975	4467064..4468266	-	1203	WP_202944168.1	hypothetical protein	-
CJA_RS17980	4468461..4470578	-	2118	WP_012489301.1	ATP-dependent helicase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	4444828..4554472	109644

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-72)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11805.62 Da
• Isoelectric Point: 4.5702

>T22947 WP_012489297.1 NC_010995:c4465614-4465312 [Cellvibrio japonicus Ueda107]
MVEVIWTEPALQELDAIAEYIALDNPAAASRLVQDVFEKMERLERFPDSGRLPPELPHSIYREVVIPPCRVFYREDQQRI
FILFVLREERQLRAYMLGNS

Nucleotide

• Length: 303 bp

>T22947 NC_010995:c4465614-4465312 [Cellvibrio japonicus Ueda107]
ATGGTTGAGGTAATCTGGACGGAGCCAGCTCTTCAGGAGTTGGATGCCATCGCTGAGTACATCGCTTTGGATAATCCTGC
TGCGGCAAGTCGCTTGGTACAGGACGTTTTTGAAAAAATGGAGCGTTTAGAGCGTTTTCCTGACTCTGGGCGACTCCCCC
CAGAGCTGCCTCATTCGATATATCGAGAAGTGGTGATTCCGCCTTGCCGGGTTTTTTATCGTGAGGATCAGCAACGGATT
TTCATCCTTTTCGTCCTGCGAGAGGAGCGGCAACTTCGTGCGTATATGCTTGGAAACAGTTAG

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9895.38 Da
• Isoelectric Point: 8.5256

>AT22947 WP_041552696.1 NC_010995:c4465859-4465602 [Cellvibrio japonicus Ueda107]
MKVELVTNLKRQATKILADLHTSKEPVLITEHGQPSAYLVDVADYEFMQRRLELLEGLSRGERAVLEGRTYNLNEARERL
SKWLR

Nucleotide

• Length: 258 bp

>AT22947 NC_010995:c4465859-4465602 [Cellvibrio japonicus Ueda107]
ATGAAGGTTGAGCTTGTTACAAACCTTAAGCGCCAGGCCACTAAAATTCTGGCGGACCTGCACACATCGAAAGAGCCTGT
GCTGATTACGGAGCATGGGCAGCCATCGGCATACCTTGTTGATGTGGCGGATTATGAATTTATGCAACGCAGGCTTGAGC
TGCTTGAAGGTCTTTCAAGAGGAGAGCGTGCTGTGCTTGAAGGAAGGACCTACAACCTAAACGAGGCTCGGGAGAGACTG
AGTAAATGGTTGAGGTAA

Structures

Toxin

• AlphaFold DB: B3PHY2