Detailed information of TA system TA229467

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Hha-TomB/-
• Location: 3418469..3419089
• Replicon: chromosome
• Accession: NZ_CP089799
• Organism: Salmonella enterica subsp. enterica serovar Kentucky strain ZTA19/00785

Toxin (Protein)

• Gene name: Hha
• Uniprot ID: V1H8E6
• Locus tag: LUY21_RS16735
• Protein ID: WP_001280991.1
• Coordinates: 3418871..3419089 (+)
• Length: 73 a.a.

Antitoxin (Protein)

• Gene name: TomB
• Uniprot ID: V1H4V6
• Locus tag: LUY21_RS16730
• Protein ID: WP_000344807.1
• Coordinates: 3418469..3418843 (+)
• Length: 125 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LUY21_RS16720 (3413608)	3413608..3414801	+	1194	WP_001039199.1	multidrug efflux RND transporter periplasmic adaptor subunit AcrA	-
LUY21_RS16725 (3414824)	3414824..3417973	+	3150	WP_001132508.1	efflux RND transporter permease AcrB	-
LUY21_RS16730 (3418469)	3418469..3418843	+	375	WP_000344807.1	Hha toxicity modulator TomB	Antitoxin
LUY21_RS16735 (3418871)	3418871..3419089	+	219	WP_001280991.1	HHA domain-containing protein	Toxin
LUY21_RS16740 (3419268)	3419268..3419819	+	552	WP_001278793.1	maltose O-acetyltransferase	-
LUY21_RS16745 (3419937)	3419937..3420407	+	471	WP_000136183.1	YlaC family protein	-
LUY21_RS16750 (3420463)	3420463..3420603	-	141	WP_001197749.1	type B 50S ribosomal protein L36	-
LUY21_RS16755 (3420609)	3420609..3420869	-	261	WP_000801415.1	type B 50S ribosomal protein L31	-
LUY21_RS16760 (3421094)	3421094..3422644	+	1551	WP_000213145.1	EAL domain-containing protein	-
LUY21_RS16770 (3422875)	3422875..3423264	+	390	WP_023224410.1	MGMT family protein	-
LUY21_RS16775 (3423297)	3423297..3423866	-	570	WP_000779802.1	YbaY family lipoprotein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Haemolysin expression modulating, HHA (13-69)

Antitoxin

• Biofilm formation regulator YbaJ (1-116)

Sequences

Toxin

Protein

• Length: 73 a.a.
• Molecular weight: 8613.97 Da
• Isoelectric Point: 8.9008

>T229467 WP_001280991.1 NZ_CP089799:3418871-3419089 [Salmonella enterica subsp. enterica serovar Kentucky]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Nucleotide

• Length: 219 bp

>T229467 NZ_CP124481:889568-889945 [Escherichia coli]
ATGAAAACATTACCTGATACACACGTACGGAAGGTATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTGAACTTTCTCGTGGAAAAATACGCACTGGTACGTACCGACCTGCCGGGATTC
AGCGCCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCAACAGGCCTGATGATCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGGAAGCATCCGGAGGCGAAACGATGA

Antitoxin

Protein

• Length: 125 a.a.
• Molecular weight: 14453.27 Da
• Isoelectric Point: 5.1444

>AT229467 WP_000344807.1 NZ_CP089799:3418469-3418843 [Salmonella enterica subsp. enterica serovar Kentucky]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Nucleotide

• Length: 375 bp

>AT229467 NZ_CP124481:889111-889479 [Escherichia coli]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGATGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGCGCTCGTCTGGTGCAAGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAATTAATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCGAAAGGACTGACCTGCGAAGCCGACACCCTCGGCAGTTG
TGGTTACGTTTATCTGGCTTTTTATCCAACATCCGAAACGAAAAAGTAA

Structures

Toxin

• PDB: 4ICG

Antitoxin

• AlphaFold DB: A0A5I5FGI0