229466

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2427491..2428013 Replicon chromosome
Accession NZ_CP089799
Organism Salmonella enterica subsp. enterica serovar Kentucky strain ZTA19/00785

Toxin (Protein)


Gene name stbE Uniprot ID V7IL40
Locus tag LUY21_RS11860 Protein ID WP_000221345.1
Coordinates 2427729..2428013 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag LUY21_RS11855 Protein ID WP_000885424.1
Coordinates 2427491..2427739 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LUY21_RS11825 (2423017) 2423017..2423925 - 909 WP_052939372.1 LysR family transcriptional regulator -
LUY21_RS11830 (2424327) 2424327..2424515 + 189 WP_001276021.1 DUF29 family protein -
LUY21_RS11835 (2424881) 2424881..2425620 + 740 Protein_2316 hypothetical protein -
LUY21_RS11840 (2425622) 2425622..2426530 - 909 WP_077906523.1 hypothetical protein -
LUY21_RS11845 (2426803) 2426803..2427134 - 332 Protein_2318 DUF1493 family protein -
LUY21_RS11850 (2427220) 2427220..2427339 - 120 Protein_2319 type II and III secretion system -
LUY21_RS11855 (2427491) 2427491..2427739 + 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
LUY21_RS11860 (2427729) 2427729..2428013 + 285 WP_000221345.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LUY21_RS11865 (2428184) 2428184..2428573 + 390 WP_000194089.1 RidA family protein -
LUY21_RS11870 (2428625) 2428625..2429704 - 1080 WP_023203126.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
LUY21_RS11875 (2429897) 2429897..2430385 - 489 WP_023223899.1 MarR family winged helix-turn-helix transcriptional regulator -
LUY21_RS11880 (2430430) 2430430..2431938 + 1509 WP_023223898.1 FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2420145..2434795 14650


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11043.79 Da        Isoelectric Point: 10.6500

>T229466 WP_000221345.1 NZ_CP089799:2427729-2428013 [Salmonella enterica subsp. enterica serovar Kentucky]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKVTRHRS

Download         Length: 285 bp

>T229466 NZ_CP124481:680776-680949 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTTCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT229466 WP_000885424.1 NZ_CP089799:2427491-2427739 [Salmonella enterica subsp. enterica serovar Kentucky]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp

>AT229466 NZ_CP124481:680452-680748 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCCGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAGCATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5Y2FFA8

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References