Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4290435..4291216 Replicon chromosome
Accession NZ_CP089798
Organism Salmonella enterica subsp. enterica serovar Kentucky strain ZTA19/00789

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A3G3E5T9
Locus tag LUY14_RS20820 Protein ID WP_000625911.1
Coordinates 4290435..4290926 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID V7IUD2
Locus tag LUY14_RS20825 Protein ID WP_001271379.1
Coordinates 4290923..4291216 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LUY14_RS20795 (4285571) 4285571..4288009 - 2439 WP_023224120.1 F4 (K88) fimbrial usher FaeD -
LUY14_RS20800 (4288019) 4288019..4288558 - 540 WP_000721295.1 type 1 fimbrial protein -
LUY14_RS20805 (4288593) 4288593..4288883 - 291 WP_000773469.1 PapB/FocB family fimbrial expression transcriptional regulator -
LUY14_RS20810 (4289470) 4289470..4289697 + 228 WP_001112992.1 hypothetical protein -
LUY14_RS20815 (4289972) 4289972..4290220 - 249 Protein_4071 IS481 family transposase -
LUY14_RS20820 (4290435) 4290435..4290926 - 492 WP_000625911.1 GNAT family N-acetyltransferase Toxin
LUY14_RS20825 (4290923) 4290923..4291216 - 294 WP_001271379.1 DUF1778 domain-containing protein Antitoxin
LUY14_RS20830 (4291534) 4291534..4291755 + 222 WP_052939504.1 hypothetical protein -
LUY14_RS20835 (4292021) 4292021..4292896 + 876 WP_023205266.1 AraC family transcriptional regulator -
LUY14_RS20840 (4292893) 4292893..4293180 + 288 WP_072103482.1 transcriptional regulator RtsB -
LUY14_RS20845 (4293173) 4293173..4293355 - 183 WP_072106065.1 ATP-binding cassette domain-containing protein -
LUY14_RS20850 (4293375) 4293375..4293474 + 100 Protein_4078 hypothetical protein -
LUY14_RS20855 (4293522) 4293522..4293716 + 195 WP_223163373.1 hypothetical protein -
LUY14_RS20860 (4294011) 4294011..4294916 - 906 WP_001268192.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - faeI / faeH / faeF / faeE / faeD / faeC 4277413..4293355 15942


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-144)

Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17663.44 Da        Isoelectric Point: 7.2655

>T229451 WP_000625911.1 NZ_CP089798:c4290926-4290435 [Salmonella enterica subsp. enterica serovar Kentucky]
MISSPEPLHAGHILTPFCCGVDSMDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTAPGRFRRNMPDP
IPIVVLGRLAVDKSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFEPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

>T229451 NZ_CP124475:2839013-2839120 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACAACCTGGCGGCACCGATCCTGGCGGGGATTATTACCGCAGTGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10938.54 Da        Isoelectric Point: 9.8590

>AT229451 WP_001271379.1 NZ_CP089798:c4291216-4290923 [Salmonella enterica subsp. enterica serovar Kentucky]
MSAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT229451 NZ_CP124475:c2838956-2838901 [Escherichia coli]
CAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G3E5T9

Antitoxin

Source ID Structure
AlphaFold DB V7IUD2

References