Detailed information of TA system TA022945

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 4313978..4314612
• Replicon: chromosome
• Accession: NC_010995
• Organism: Cellvibrio japonicus Ueda107

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: CJA_RS17385
• Protein ID: WP_041551765.1
• Coordinates: 4313978..4314379 (-)
• Length: 134 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: B3PH13
• Locus tag: CJA_RS17390
• Protein ID: WP_012489183.1
• Coordinates: 4314379..4314612 (-)
• Length: 78 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CJA_RS17375	4310619..4311875	+	1257	WP_012489180.1	HlyD family efflux transporter periplasmic adaptor subunit	-
CJA_RS17380	4311872..4313560	+	1689	WP_041551763.1	hypothetical protein	-
CJA_RS17385	4313978..4314379	-	402	WP_041551765.1	tRNA(fMet)-specific endonuclease VapC	Toxin
CJA_RS17390	4314379..4314612	-	234	WP_012489183.1	antitoxin	Antitoxin
CJA_RS17395	4314683..4315576	-	894	WP_012489184.1	LysR family transcriptional regulator	-
CJA_RS17400	4315749..4316180	+	432	WP_012489185.1	DoxX family protein	-
CJA_RS17405	4316236..4316928	+	693	WP_012489186.1	pirin family protein	-
CJA_RS17410	4316955..4317248	+	294	WP_012489187.1	type II toxin-antitoxin system RelE/ParE family toxin	-
CJA_RS17415	4317258..4317575	+	318	WP_012489188.1	HigA family addiction module antidote protein	-
CJA_RS17420	4317657..4317899	+	243	WP_148208925.1	hypothetical protein	-
CJA_RS17425	4317944..4319059	-	1116	WP_012489189.1	ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	4242549..4331763	89214

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-125)

Antitoxin

• SpoVT-AbrB domain (7-54)

Sequences

Toxin

Protein

• Length: 134 a.a.
• Molecular weight: 15007.20 Da
• Isoelectric Point: 7.1293

>T22945 WP_041551765.1 NC_010995:c4314379-4313978 [Cellvibrio japonicus Ueda107]
MLKYMLDTNIVIYVIKRRPIEALETFNRHAGQLCISSITLAELLHGAEKSAKPEHNLHQVEEFVSRLQVLDYGNKAAAHY
GDIRAQLERQGTPIGVNDLHIAGHARSEGLVLVTNNLREFERVAALRLENWLG

Nucleotide

• Length: 402 bp

>T22945 NC_010995:c4314379-4313978 [Cellvibrio japonicus Ueda107]
ATGCTGAAATATATGCTGGATACCAATATCGTTATCTACGTCATTAAACGTCGTCCAATTGAAGCACTGGAAACATTTAA
TCGCCATGCCGGTCAGCTTTGTATCAGCAGTATCACCCTGGCGGAATTACTGCACGGTGCGGAAAAAAGTGCGAAGCCTG
AACATAATCTCCACCAGGTTGAAGAGTTTGTATCGCGCTTGCAGGTATTGGATTACGGCAATAAAGCGGCAGCCCATTAC
GGGGATATTCGTGCACAGCTGGAACGTCAAGGTACTCCCATAGGCGTTAACGATTTACATATCGCTGGTCATGCACGCAG
TGAAGGCTTGGTGTTGGTAACCAATAACCTGCGCGAGTTTGAACGAGTGGCTGCATTACGCCTGGAAAATTGGCTGGGCT
GA

Antitoxin

Protein

• Length: 78 a.a.
• Molecular weight: 8704.73 Da
• Isoelectric Point: 4.7672

>AT22945 WP_012489183.1 NC_010995:c4314612-4314379 [Cellvibrio japonicus Ueda107]
MATGSVFVNNRTQAVRLPAEVRFPDEVKKVHVRVMGPDRILSPADKTWDSFFLGGESVSDDFMTERASQEQSEREAF

Nucleotide

• Length: 234 bp

>AT22945 NC_010995:c4314612-4314379 [Cellvibrio japonicus Ueda107]
ATGGCAACAGGTTCGGTATTTGTAAATAACCGCACTCAAGCAGTGCGTTTGCCTGCGGAGGTGCGTTTTCCTGATGAGGT
GAAGAAAGTACATGTGCGGGTAATGGGGCCAGATCGTATCCTGTCTCCTGCTGATAAAACCTGGGATAGTTTTTTCCTCG
GTGGTGAGTCTGTCAGTGATGATTTTATGACGGAGCGAGCCAGCCAGGAGCAATCTGAGCGGGAAGCTTTTTGA

Structures

Antitoxin

• AlphaFold DB: B3PH13