Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3419103..3419723 Replicon chromosome
Accession NZ_CP089798
Organism Salmonella enterica subsp. enterica serovar Kentucky strain ZTA19/00789

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag LUY14_RS16730 Protein ID WP_001280991.1
Coordinates 3419505..3419723 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag LUY14_RS16725 Protein ID WP_000344807.1
Coordinates 3419103..3419477 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LUY14_RS16715 (3414242) 3414242..3415435 + 1194 WP_001039199.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
LUY14_RS16720 (3415458) 3415458..3418607 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
LUY14_RS16725 (3419103) 3419103..3419477 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
LUY14_RS16730 (3419505) 3419505..3419723 + 219 WP_001280991.1 HHA domain-containing protein Toxin
LUY14_RS16735 (3419902) 3419902..3420453 + 552 WP_001278793.1 maltose O-acetyltransferase -
LUY14_RS16740 (3420571) 3420571..3421041 + 471 WP_000136183.1 YlaC family protein -
LUY14_RS16745 (3421097) 3421097..3421237 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
LUY14_RS16750 (3421243) 3421243..3421503 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
LUY14_RS16755 (3421728) 3421728..3423278 + 1551 WP_000213145.1 EAL domain-containing protein -
LUY14_RS16765 (3423509) 3423509..3423898 + 390 WP_023224410.1 MGMT family protein -
LUY14_RS16770 (3423931) 3423931..3424500 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T229446 WP_001280991.1 NZ_CP089798:3419505-3419723 [Salmonella enterica subsp. enterica serovar Kentucky]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T229446 NZ_CP124475:1899655-1899906 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT229446 WP_000344807.1 NZ_CP089798:3419103-3419477 [Salmonella enterica subsp. enterica serovar Kentucky]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT229446 NZ_CP124475:1899903-1900157 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAAATTATCAAAGATACACGCAGAACACCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GCTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References