Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 864637..865297 Replicon chromosome
Accession NZ_CP089798
Organism Salmonella enterica subsp. enterica serovar Kentucky strain ZTA19/00789

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag LUY14_RS04265 Protein ID WP_000244756.1
Coordinates 864884..865297 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag LUY14_RS04260 Protein ID WP_000351186.1
Coordinates 864637..864903 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LUY14_RS04240 (860566) 860566..861999 - 1434 WP_001230143.1 6-phospho-beta-glucosidase BglA -
LUY14_RS04245 (862157) 862157..862468 + 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
LUY14_RS04250 (862632) 862632..863291 + 660 WP_000250289.1 hemolysin III family protein -
LUY14_RS04255 (863407) 863407..864387 - 981 WP_000874178.1 tRNA-modifying protein YgfZ -
LUY14_RS04260 (864637) 864637..864903 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
LUY14_RS04265 (864884) 864884..865297 + 414 WP_000244756.1 protein YgfX Toxin
LUY14_RS04270 (865350) 865350..865871 - 522 WP_001055885.1 flavodoxin FldB -
LUY14_RS04275 (865984) 865984..866880 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
LUY14_RS04280 (866904) 866904..867617 + 714 WP_023223829.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LUY14_RS04285 (867623) 867623..869356 + 1734 WP_023223830.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T229435 WP_000244756.1 NZ_CP089798:864884-865297 [Salmonella enterica subsp. enterica serovar Kentucky]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

>T229435 NZ_CP124471:c4425419-4425246 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTTCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT229435 WP_000351186.1 NZ_CP089798:864637-864903 [Salmonella enterica subsp. enterica serovar Kentucky]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT229435 NZ_CP124471:c4425743-4425447 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCCGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAGCATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References