Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
Location | 195163..195923 | Replicon | chromosome |
Accession | NZ_CP089798 | ||
Organism | Salmonella enterica subsp. enterica serovar Kentucky strain ZTA19/00789 |
Toxin (Protein)
Gene name | tacT | Uniprot ID | A0A5H3Y7E3 |
Locus tag | LUY14_RS00920 | Protein ID | WP_023225088.1 |
Coordinates | 195438..195923 (+) | Length | 162 a.a. |
Antitoxin (Protein)
Gene name | tacA | Uniprot ID | A0A3Z2K6C6 |
Locus tag | LUY14_RS00915 | Protein ID | WP_072106018.1 |
Coordinates | 195163..195450 (+) | Length | 96 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
LUY14_RS00900 (191591) | 191591..192019 | + | 429 | Protein_179 | IS3 family transposase | - |
LUY14_RS00905 (192215) | 192215..192985 | - | 771 | WP_000456879.1 | DUF3800 domain-containing protein | - |
LUY14_RS00910 (194012) | 194012..195040 | + | 1029 | WP_023196719.1 | HNH endonuclease signature motif containing protein | - |
LUY14_RS00915 (195163) | 195163..195450 | + | 288 | WP_072106018.1 | DUF1778 domain-containing protein | Antitoxin |
LUY14_RS00920 (195438) | 195438..195923 | + | 486 | WP_023225088.1 | GNAT family N-acetyltransferase | Toxin |
LUY14_RS00925 (196293) | 196293..196832 | - | 540 | WP_000047141.1 | copper-binding periplasmic metallochaperone CueP | - |
LUY14_RS00930 (197005) | 197005..197217 | - | 213 | WP_000014594.1 | RNA chaperone/antiterminator CspA | - |
LUY14_RS00935 (197505) | 197505..197795 | - | 291 | WP_000455790.1 | HTH-type transcriptional regulator | - |
LUY14_RS00940 (198234) | 198234..198944 | + | 711 | WP_000190524.1 | DUF3053 domain-containing protein | - |
LUY14_RS00945 (198994) | 198994..199968 | - | 975 | WP_023225087.1 | glyoxylate/hydroxypyruvate reductase GhrB | - |
LUY14_RS00950 (200187) | 200187..200849 | - | 663 | WP_000747548.1 | OmpA family lipoprotein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 162 a.a. Molecular weight: 17756.43 Da Isoelectric Point: 9.0965
>T229433 WP_023225088.1 NZ_CP089798:195438-195923 [Salmonella enterica subsp. enterica serovar Kentucky]
VGHVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHEKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q
VGHVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHEKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q
Download Length: 486 bp
>T229433 NZ_CP124471:c4146067-4145780 [Escherichia coli]
ATGCCAATGGAGTTTGAATGGGATGAAAACAAGGCCAAAAGTAATCGGGTGAAACATGGCATCCGCTTTGAAGATGCGGT
GTTATTGTTTGATGATCCACAACATTTGTCACAGCAAGAACGCATAGAAAACGGTGAGTATCGCTGGCAGACAATCGGCC
TGGTTTACGGCATCGTGGTTATTCTGGTTGCGCATACCATCCGTTTCGAAAGCGGAAATGAAATTATTCGAATCATCAGT
GCACGAAAAGCAGATCGTAAAGAGAGGAATCGCTATGAGCATGGTTAA
ATGCCAATGGAGTTTGAATGGGATGAAAACAAGGCCAAAAGTAATCGGGTGAAACATGGCATCCGCTTTGAAGATGCGGT
GTTATTGTTTGATGATCCACAACATTTGTCACAGCAAGAACGCATAGAAAACGGTGAGTATCGCTGGCAGACAATCGGCC
TGGTTTACGGCATCGTGGTTATTCTGGTTGCGCATACCATCCGTTTCGAAAGCGGAAATGAAATTATTCGAATCATCAGT
GCACGAAAAGCAGATCGTAAAGAGAGGAATCGCTATGAGCATGGTTAA
Antitoxin
Download Length: 96 a.a. Molecular weight: 10982.66 Da Isoelectric Point: 4.6811
>AT229433 WP_072106018.1 NZ_CP089798:195163-195450 [Salmonella enterica subsp. enterica serovar Kentucky]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDM
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDM
Download Length: 288 bp
>AT229433 NZ_CP124471:c4145793-4145491 [Escherichia coli]
ATGAGCATGGTTAAACATAAACGAGGGACCTCCTCTACACTCGATGTGCAGCATGAGGCCGAACTGAAGGCGCTGGCGAA
TAAATCCGACGAAGATATTGATTACAGTGATATCCCACCTTCCAGCGATGAGCAATGGTCTAACGCCGAACGCGGTAAGT
TTTATCGGCCATTGAAAACTCAGGCTTCGGTGCGTATTGATGCTGATGTGATGGAATGGTTGAAGCGACCAGGTAAAGGC
TATCAAACTCGCCTGAACGCAATTTTACGTGAAGCGATGCTGCGCGATCAGAACAAAAAATAA
ATGAGCATGGTTAAACATAAACGAGGGACCTCCTCTACACTCGATGTGCAGCATGAGGCCGAACTGAAGGCGCTGGCGAA
TAAATCCGACGAAGATATTGATTACAGTGATATCCCACCTTCCAGCGATGAGCAATGGTCTAACGCCGAACGCGGTAAGT
TTTATCGGCCATTGAAAACTCAGGCTTCGGTGCGTATTGATGCTGATGTGATGGAATGGTTGAAGCGACCAGGTAAAGGC
TATCAAACTCGCCTGAACGCAATTTTACGTGAAGCGATGCTGCGCGATCAGAACAAAAAATAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A5H3Y7E3 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A3Z2K6C6 |