Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-yefM/YoeB-RelB
Location 3493066..3493579 Replicon chromosome
Accession NC_010995
Organism Cellvibrio japonicus Ueda107

Toxin (Protein)


Gene name relB Uniprot ID B3PCR8
Locus tag CJA_RS14315 Protein ID WP_012488559.1
Coordinates 3493313..3493579 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID B3PCR7
Locus tag CJA_RS14310 Protein ID WP_012488558.1
Coordinates 3493066..3493320 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CJA_RS14285 3488545..3490482 - 1938 WP_012488553.1 acetate--CoA ligase -
CJA_RS14290 3490671..3490916 - 246 WP_012488554.1 hypothetical protein -
CJA_RS14295 3491007..3491387 - 381 WP_012488555.1 aspartate 1-decarboxylase -
CJA_RS14300 3491420..3492271 - 852 WP_012488556.1 pantoate--beta-alanine ligase -
CJA_RS14305 3492398..3492904 - 507 WP_012488557.1 MOSC domain-containing protein -
CJA_RS14310 3493066..3493320 + 255 WP_012488558.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
CJA_RS14315 3493313..3493579 + 267 WP_012488559.1 Txe/YoeB family addiction module toxin Toxin
CJA_RS14320 3493576..3494964 - 1389 WP_041552454.1 replicative DNA helicase -
CJA_RS14325 3495105..3495551 - 447 WP_012488561.1 50S ribosomal protein L9 -
CJA_RS14330 3495566..3495793 - 228 WP_012488562.1 30S ribosomal protein S18 -
CJA_RS14335 3495797..3496240 - 444 WP_012488563.1 30S ribosomal protein S6 -
CJA_RS19475 3496250..3496399 - 150 WP_158304071.1 hypothetical protein -
CJA_RS19150 3496704..3498416 + 1713 WP_012488564.1 cellulase family glycosylhydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(7-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10581.99 Da        Isoelectric Point: 8.8895

>T22943 WP_012488559.1 NC_010995:3493313-3493579 [Cellvibrio japonicus Ueda107]
MTRSLAWTDAAWSDYLYWQGQDRKTLKRINQLIRETLREPFQGIGKPEPLKESLAGFWSRRIDDTHRLVYAVDDNHLTII
ACRYHYER

Download         Length: 267 bp

>T22943 NC_010995:3493313-3493579 [Cellvibrio japonicus Ueda107]
ATGACTAGGTCACTGGCATGGACTGATGCCGCCTGGAGCGACTATCTCTACTGGCAGGGGCAGGATCGAAAAACCCTCAA
GCGGATCAACCAACTTATCCGCGAAACCTTGCGTGAACCCTTTCAGGGAATCGGCAAGCCGGAACCACTCAAGGAAAGCC
TCGCCGGTTTCTGGTCGCGCCGGATTGATGATACCCATCGCTTGGTTTATGCCGTAGACGACAACCATTTAACTATCATC
GCCTGTCGTTACCACTACGAACGCTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9303.39 Da        Isoelectric Point: 4.9877

>AT22943 WP_012488558.1 NC_010995:3493066-3493320 [Cellvibrio japonicus Ueda107]
MNVTTFSDARNNLKSLLDRVTQDADCTIITRRDAGDAVVMSLDYYNSLMETVHLLKSPANAAHLAESIAQYRAGKTREQA
LTDD

Download         Length: 255 bp

>AT22943 NC_010995:3493066-3493320 [Cellvibrio japonicus Ueda107]
ATGAACGTCACCACATTCAGCGATGCGCGCAACAACTTGAAAAGCTTGCTCGATAGGGTTACCCAAGACGCCGATTGCAC
CATCATCACCCGCCGCGATGCCGGTGATGCTGTCGTCATGTCGCTGGACTACTACAACAGCCTGATGGAAACCGTACACC
TGCTCAAATCCCCCGCCAATGCCGCCCACCTGGCAGAATCCATTGCGCAATACCGCGCCGGTAAAACCCGGGAGCAGGCA
TTAACGGATGACTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB B3PCR8

Antitoxin

Source ID Structure
AlphaFold DB B3PCR7

References