Detailed information of TA system TA229425

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Hha-TomB/-
• Location: 3418931..3419551
• Replicon: chromosome
• Accession: NZ_CP089797
• Organism: Salmonella enterica subsp. enterica serovar Kentucky strain ZTA19/00790

Toxin (Protein)

• Gene name: Hha
• Uniprot ID: V1H8E6
• Locus tag: LUY11_RS16730
• Protein ID: WP_001280991.1
• Coordinates: 3419333..3419551 (+)
• Length: 73 a.a.

Antitoxin (Protein)

• Gene name: TomB
• Uniprot ID: V1H4V6
• Locus tag: LUY11_RS16725
• Protein ID: WP_000344807.1
• Coordinates: 3418931..3419305 (+)
• Length: 125 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LUY11_RS16715 (3414070)	3414070..3415263	+	1194	WP_001039199.1	multidrug efflux RND transporter periplasmic adaptor subunit AcrA	-
LUY11_RS16720 (3415286)	3415286..3418435	+	3150	WP_001132508.1	efflux RND transporter permease AcrB	-
LUY11_RS16725 (3418931)	3418931..3419305	+	375	WP_000344807.1	Hha toxicity modulator TomB	Antitoxin
LUY11_RS16730 (3419333)	3419333..3419551	+	219	WP_001280991.1	HHA domain-containing protein	Toxin
LUY11_RS16735 (3419730)	3419730..3420281	+	552	WP_001278793.1	maltose O-acetyltransferase	-
LUY11_RS16740 (3420399)	3420399..3420869	+	471	WP_000136183.1	YlaC family protein	-
LUY11_RS16745 (3420925)	3420925..3421065	-	141	WP_001197749.1	type B 50S ribosomal protein L36	-
LUY11_RS16750 (3421071)	3421071..3421331	-	261	WP_000801415.1	type B 50S ribosomal protein L31	-
LUY11_RS16755 (3421556)	3421556..3423106	+	1551	WP_000213145.1	EAL domain-containing protein	-
LUY11_RS16765 (3423337)	3423337..3423726	+	390	WP_023224410.1	MGMT family protein	-
LUY11_RS16770 (3423759)	3423759..3424328	-	570	WP_000779802.1	YbaY family lipoprotein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Haemolysin expression modulating, HHA (13-69)

Antitoxin

• Biofilm formation regulator YbaJ (1-116)

Sequences

Toxin

Protein

• Length: 73 a.a.
• Molecular weight: 8613.97 Da
• Isoelectric Point: 8.9008

>T229425 WP_001280991.1 NZ_CP089797:3419333-3419551 [Salmonella enterica subsp. enterica serovar Kentucky]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Nucleotide

• Length: 219 bp

>T229425 NZ_CP124471:c1896395-1896021 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTACTGGACCAGCACTATGGCCTCACACTGAATGACACACCTTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTGAACTTTCTCGTTGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin

Protein

• Length: 125 a.a.
• Molecular weight: 14453.27 Da
• Isoelectric Point: 5.1444

>AT229425 WP_000344807.1 NZ_CP089797:3418931-3419305 [Salmonella enterica subsp. enterica serovar Kentucky]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Nucleotide

• Length: 375 bp

>AT229425 NZ_CP124471:c1896852-1896484 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCAGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCCGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Structures

Toxin

• PDB: 4ICG

Antitoxin

• AlphaFold DB: A0A5I5FGI0