229424

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2427955..2428477 Replicon chromosome
Accession NZ_CP089797
Organism Salmonella enterica subsp. enterica serovar Kentucky strain ZTA19/00790

Toxin (Protein)


Gene name stbE Uniprot ID V7IL40
Locus tag LUY11_RS11855 Protein ID WP_000221345.1
Coordinates 2428193..2428477 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag LUY11_RS11850 Protein ID WP_000885424.1
Coordinates 2427955..2428203 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LUY11_RS11820 (2423481) 2423481..2424389 - 909 WP_052939372.1 LysR family transcriptional regulator -
LUY11_RS11825 (2424791) 2424791..2424979 + 189 WP_001276021.1 DUF29 family protein -
LUY11_RS11830 (2425345) 2425345..2426084 + 740 Protein_2317 hypothetical protein -
LUY11_RS11835 (2426086) 2426086..2426994 - 909 WP_077906523.1 hypothetical protein -
LUY11_RS11840 (2427267) 2427267..2427598 - 332 Protein_2319 DUF1493 family protein -
LUY11_RS11845 (2427684) 2427684..2427803 - 120 Protein_2320 type II and III secretion system -
LUY11_RS11850 (2427955) 2427955..2428203 + 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
LUY11_RS11855 (2428193) 2428193..2428477 + 285 WP_000221345.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LUY11_RS11860 (2428648) 2428648..2429037 + 390 WP_000194089.1 RidA family protein -
LUY11_RS11865 (2429089) 2429089..2430168 - 1080 WP_023203126.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
LUY11_RS11870 (2430361) 2430361..2430849 - 489 WP_023223899.1 MarR family winged helix-turn-helix transcriptional regulator -
LUY11_RS11875 (2430894) 2430894..2432402 + 1509 WP_023223898.1 FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2420609..2435259 14650


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11043.79 Da        Isoelectric Point: 10.6500

>T229424 WP_000221345.1 NZ_CP089797:2428193-2428477 [Salmonella enterica subsp. enterica serovar Kentucky]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKVTRHRS

Download         Length: 285 bp

>T229424 NZ_CP124471:1883359-1883613 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAAATTATCAAAGATACACGCAGAACACCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GCTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT229424 WP_000885424.1 NZ_CP089797:2427955-2428203 [Salmonella enterica subsp. enterica serovar Kentucky]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp

>AT229424 NZ_CP124471:1883111-1883362 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5Y2FFA8

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References