Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1032634..1033448 Replicon chromosome
Accession NZ_CP089797
Organism Salmonella enterica subsp. enterica serovar Kentucky strain ZTA19/00790

Toxin (Protein)


Gene name TacT3 Uniprot ID A0A3G3DUX8
Locus tag LUY11_RS05035 Protein ID WP_000971653.1
Coordinates 1032634..1033161 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID M7S6I2
Locus tag LUY11_RS05040 Protein ID WP_000855694.1
Coordinates 1033158..1033448 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LUY11_RS05005 (1029008) 1029008..1029406 + 399 Protein_982 cytoplasmic protein -
LUY11_RS05010 (1029617) 1029617..1029835 + 219 Protein_983 hypothetical protein -
LUY11_RS05015 (1029992) 1029992..1030660 + 669 WP_000445914.1 hypothetical protein -
LUY11_RS05020 (1030687) 1030687..1031181 + 495 WP_000424946.1 hypothetical protein -
LUY11_RS05025 (1031353) 1031353..1032009 - 657 WP_023225036.1 protein-serine/threonine phosphatase -
LUY11_RS05030 (1032359) 1032359..1032561 + 203 Protein_987 IS5/IS1182 family transposase -
LUY11_RS05035 (1032634) 1032634..1033161 - 528 WP_000971653.1 GNAT family N-acetyltransferase Toxin
LUY11_RS05040 (1033158) 1033158..1033448 - 291 WP_000855694.1 DUF1778 domain-containing protein Antitoxin
LUY11_RS05045 (1033719) 1033719..1033919 - 201 Protein_990 transposase -
LUY11_RS05050 (1034160) 1034160..1034486 + 327 WP_000393295.1 hypothetical protein -
LUY11_RS05055 (1034759) 1034759..1035106 - 348 WP_001555786.1 DUF1493 family protein -
LUY11_RS05060 (1035091) 1035091..1035540 - 450 WP_023225038.1 hypothetical protein -
LUY11_RS05065 (1035972) 1035972..1036415 - 444 WP_023225039.1 SPI-1 type III secretion system invasion lipoprotein InvH -
LUY11_RS05070 (1036873) 1036873..1037523 + 651 WP_072203970.1 type III secretion system transcriptional activator InvF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - invH / invF / invG / invE / invA / invB 1031353..1042836 11483
- inside IScluster/Tn - - 1032385..1033919 1534


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19043.87 Da        Isoelectric Point: 9.7032

>T229415 WP_000971653.1 NZ_CP089797:c1033161-1032634 [Salmonella enterica subsp. enterica serovar Kentucky]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRHDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

>T229415 NZ_CP124469:30931-31452 [Escherichia coli]
GTGAGCAATACAACGATAGAGATTTTCTCTGGAGAGAAAGATTATGATCTAAACGGTTTTGATTGCGGCGAAGAGTCACT
AAACGCCTTTTTAGCCAACCACTTAAAAAGGCAGCATGAGGGAAAAATTCTTCGTGCTTATGTGCTTTGCACTCAAGAAG
AAAGGCCAAAAGTGTTAGGGTATTACACTTTGTCAGGTAGTTGTTTTGAAAAGGAGTCCTTACCTTCACGAAGCAAACAA
AAGAAGGTTCCTTATCGGAATGTTCCAAGTGTTACTTTGGGTAGGCTGGCTTTGGACAAGTCCCTTCAAGGTCAAGGATT
TGGCTCAATGCTTGTAACACATGCAATGCGCGTTGTGTACAATGCATCTCTTGCTGTAGGCATTCATGGACTTTTCGTTG
AGGCGTTAAATGACAAAGCCAAGGCGTTTTATAAAAGTTTAGGCTTTATCCAGCTGGTTGGTAACAACGAGCGTTCTTTG
TTCTATCCTACAAAATCTATCGAAAAATTGTTCGAAGAATAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.50 Da        Isoelectric Point: 6.3133

>AT229415 WP_000855694.1 NZ_CP089797:c1033448-1033158 [Salmonella enterica subsp. enterica serovar Kentucky]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp

>AT229415 NZ_CP124469:30654-30923 [Escherichia coli]
ATGTCAGCACTAAAAAAGCAGCGCATCGATTTGAGATTAACCGATGACGATAAAAGCATCATCGAGGAAGCTGCCGCAAT
GTCTAACCAGAGCATTACTCAGTTTATGGTTAGCAGTGCATCTGAACGTGCCGTGAAAGTTATAGAGCAACACCGTAGAC
TAGTTCTGAATGAAGAATCCTGGAATCTGGTTATGGACGCTATAAGCAATCCTCCGGCACCGAACGACAAGCTGAAACGA
GCTGCTGATCGTCTGAAAAGCATGGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G3DUX8

Antitoxin

Source ID Structure
AlphaFold DB A0A3V8SJE7

References