Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4288847..4289628 Replicon chromosome
Accession NZ_CP089795
Organism Salmonella enterica subsp. enterica serovar Kentucky strain ZTA19/00813

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A3G3E5T9
Locus tag LUY22_RS20810 Protein ID WP_000625911.1
Coordinates 4288847..4289338 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID V7IUD2
Locus tag LUY22_RS20815 Protein ID WP_001271379.1
Coordinates 4289335..4289628 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LUY22_RS20785 (4283983) 4283983..4286421 - 2439 WP_023224120.1 F4 (K88) fimbrial usher FaeD -
LUY22_RS20790 (4286431) 4286431..4286970 - 540 WP_000721295.1 type 1 fimbrial protein -
LUY22_RS20795 (4287005) 4287005..4287295 - 291 WP_000773469.1 PapB/FocB family fimbrial expression transcriptional regulator -
LUY22_RS20800 (4287882) 4287882..4288109 + 228 WP_001112992.1 hypothetical protein -
LUY22_RS20805 (4288384) 4288384..4288632 - 249 Protein_4076 IS481 family transposase -
LUY22_RS20810 (4288847) 4288847..4289338 - 492 WP_000625911.1 GNAT family N-acetyltransferase Toxin
LUY22_RS20815 (4289335) 4289335..4289628 - 294 WP_001271379.1 DUF1778 domain-containing protein Antitoxin
LUY22_RS20820 (4289946) 4289946..4290167 + 222 WP_052939504.1 hypothetical protein -
LUY22_RS20825 (4290432) 4290432..4291307 + 876 WP_023205266.1 AraC family transcriptional regulator -
LUY22_RS20830 (4291304) 4291304..4291591 + 288 WP_072103482.1 transcriptional regulator RtsB -
LUY22_RS20835 (4291584) 4291584..4291766 - 183 WP_072106065.1 ATP-binding cassette domain-containing protein -
LUY22_RS20840 (4291786) 4291786..4291885 + 100 Protein_4083 hypothetical protein -
LUY22_RS20845 (4291933) 4291933..4292127 + 195 WP_223163373.1 hypothetical protein -
LUY22_RS20850 (4292422) 4292422..4293327 - 906 WP_001268192.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - faeI / faeH / faeF / faeE / faeD / faeC 4275828..4291766 15938


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-144)

Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17663.44 Da        Isoelectric Point: 7.2655

>T229409 WP_000625911.1 NZ_CP089795:c4289338-4288847 [Salmonella enterica subsp. enterica serovar Kentucky]
MISSPEPLHAGHILTPFCCGVDSMDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTAPGRFRRNMPDP
IPIVVLGRLAVDKSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFEPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

>T229409 NZ_CP124467:3489429-3489647 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10938.54 Da        Isoelectric Point: 9.8590

>AT229409 WP_001271379.1 NZ_CP089795:c4289628-4289335 [Salmonella enterica subsp. enterica serovar Kentucky]
MSAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT229409 NZ_CP124467:3489029-3489403 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G3E5T9

Antitoxin

Source ID Structure
AlphaFold DB V7IUD2

References