Detailed information of TA system TA229404

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Hha-TomB/-
• Location: 3417994..3418614
• Replicon: chromosome
• Accession: NZ_CP089795
• Organism: Salmonella enterica subsp. enterica serovar Kentucky strain ZTA19/00813

Toxin (Protein)

• Gene name: Hha
• Uniprot ID: V1H8E6
• Locus tag: LUY22_RS16735
• Protein ID: WP_001280991.1
• Coordinates: 3418396..3418614 (+)
• Length: 73 a.a.

Antitoxin (Protein)

• Gene name: TomB
• Uniprot ID: V1H4V6
• Locus tag: LUY22_RS16730
• Protein ID: WP_000344807.1
• Coordinates: 3417994..3418368 (+)
• Length: 125 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LUY22_RS16720 (3413133)	3413133..3414326	+	1194	WP_001039199.1	multidrug efflux RND transporter periplasmic adaptor subunit AcrA	-
LUY22_RS16725 (3414349)	3414349..3417498	+	3150	WP_001132508.1	efflux RND transporter permease AcrB	-
LUY22_RS16730 (3417994)	3417994..3418368	+	375	WP_000344807.1	Hha toxicity modulator TomB	Antitoxin
LUY22_RS16735 (3418396)	3418396..3418614	+	219	WP_001280991.1	HHA domain-containing protein	Toxin
LUY22_RS16740 (3418793)	3418793..3419344	+	552	WP_001278793.1	maltose O-acetyltransferase	-
LUY22_RS16745 (3419462)	3419462..3419932	+	471	WP_000136183.1	YlaC family protein	-
LUY22_RS16750 (3419988)	3419988..3420128	-	141	WP_001197749.1	type B 50S ribosomal protein L36	-
LUY22_RS16755 (3420134)	3420134..3420394	-	261	WP_000801415.1	type B 50S ribosomal protein L31	-
LUY22_RS16760 (3420619)	3420619..3422169	+	1551	WP_000213145.1	EAL domain-containing protein	-
LUY22_RS16770 (3422400)	3422400..3422789	+	390	WP_023224410.1	MGMT family protein	-
LUY22_RS16775 (3422822)	3422822..3423391	-	570	WP_000779802.1	YbaY family lipoprotein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Haemolysin expression modulating, HHA (13-69)

Antitoxin

• Biofilm formation regulator YbaJ (1-116)

Sequences

Toxin

Protein

• Length: 73 a.a.
• Molecular weight: 8613.97 Da
• Isoelectric Point: 8.9008

>T229404 WP_001280991.1 NZ_CP089795:3418396-3418614 [Salmonella enterica subsp. enterica serovar Kentucky]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Nucleotide

• Length: 219 bp

>T229404 NZ_CP124467:c1876006-1875632 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTACGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAGCATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin

Protein

• Length: 125 a.a.
• Molecular weight: 14453.27 Da
• Isoelectric Point: 5.1444

>AT229404 WP_000344807.1 NZ_CP089795:3417994-3418368 [Salmonella enterica subsp. enterica serovar Kentucky]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Nucleotide

• Length: 375 bp

>AT229404 NZ_CP124467:c1876463-1876095 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
CCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCAATCAGCATACCGTCACGCTGTATGCGAAGGGGCTGGCCTGTGAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Structures

Toxin

• PDB: 4ICG

Antitoxin

• AlphaFold DB: A0A5I5FGI0