229403

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2427307..2427829 Replicon chromosome
Accession NZ_CP089795
Organism Salmonella enterica subsp. enterica serovar Kentucky strain ZTA19/00813

Toxin (Protein)


Gene name stbE Uniprot ID V7IL40
Locus tag LUY22_RS11860 Protein ID WP_000221345.1
Coordinates 2427545..2427829 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag LUY22_RS11855 Protein ID WP_000885424.1
Coordinates 2427307..2427555 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LUY22_RS11825 (2422833) 2422833..2423741 - 909 WP_052939372.1 LysR family transcriptional regulator -
LUY22_RS11830 (2424143) 2424143..2424331 + 189 WP_001276021.1 DUF29 family protein -
LUY22_RS11835 (2424697) 2424697..2425436 + 740 Protein_2319 hypothetical protein -
LUY22_RS11840 (2425438) 2425438..2426346 - 909 WP_077906523.1 hypothetical protein -
LUY22_RS11845 (2426619) 2426619..2426950 - 332 Protein_2321 DUF1493 family protein -
LUY22_RS11850 (2427036) 2427036..2427155 - 120 Protein_2322 type II and III secretion system -
LUY22_RS11855 (2427307) 2427307..2427555 + 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
LUY22_RS11860 (2427545) 2427545..2427829 + 285 WP_000221345.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LUY22_RS11865 (2428000) 2428000..2428389 + 390 WP_000194089.1 RidA family protein -
LUY22_RS11870 (2428441) 2428441..2429520 - 1080 WP_023203126.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
LUY22_RS11875 (2429713) 2429713..2430201 - 489 WP_023223899.1 MarR family winged helix-turn-helix transcriptional regulator -
LUY22_RS11880 (2430246) 2430246..2431754 + 1509 WP_023223898.1 FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2419961..2434611 14650


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11043.79 Da        Isoelectric Point: 10.6500

>T229403 WP_000221345.1 NZ_CP089795:2427545-2427829 [Salmonella enterica subsp. enterica serovar Kentucky]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKVTRHRS

Download         Length: 285 bp

>T229403 NZ_CP124467:1865557-1865811 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAAATTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAACCAGAATCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACTGATGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT229403 WP_000885424.1 NZ_CP089795:2427307-2427555 [Salmonella enterica subsp. enterica serovar Kentucky]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp

>AT229403 NZ_CP124467:1865309-1865560 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACCATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5Y2FFA8

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References