Detailed information of TA system TA229394

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 1032608..1033422
• Replicon: chromosome
• Accession: NZ_CP089795
• Organism: Salmonella enterica subsp. enterica serovar Kentucky strain ZTA19/00813

Toxin (Protein)

• Gene name: TacT3
• Uniprot ID: A0A3G3DUX8
• Locus tag: LUY22_RS05045
• Protein ID: WP_000971653.1
• Coordinates: 1032608..1033135 (-)
• Length: 176 a.a.

Antitoxin (Protein)

• Gene name: TacA3
• Uniprot ID: M7S6I2
• Locus tag: LUY22_RS05050
• Protein ID: WP_000855694.1
• Coordinates: 1033132..1033422 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LUY22_RS05015 (1028982)	1028982..1029380	+	399	Protein_983	cytoplasmic protein	-
LUY22_RS05020 (1029591)	1029591..1029809	+	219	Protein_984	hypothetical protein	-
LUY22_RS05025 (1029966)	1029966..1030634	+	669	WP_000445914.1	hypothetical protein	-
LUY22_RS05030 (1030661)	1030661..1031155	+	495	WP_000424946.1	hypothetical protein	-
LUY22_RS05035 (1031327)	1031327..1031983	-	657	WP_023225036.1	protein-serine/threonine phosphatase	-
LUY22_RS05040 (1032333)	1032333..1032535	+	203	Protein_988	IS5/IS1182 family transposase	-
LUY22_RS05045 (1032608)	1032608..1033135	-	528	WP_000971653.1	GNAT family N-acetyltransferase	Toxin
LUY22_RS05050 (1033132)	1033132..1033422	-	291	WP_000855694.1	DUF1778 domain-containing protein	Antitoxin
LUY22_RS05055 (1033693)	1033693..1033893	-	201	Protein_991	transposase	-
LUY22_RS05060 (1034134)	1034134..1034460	+	327	WP_000393295.1	hypothetical protein	-
LUY22_RS05065 (1034733)	1034733..1035080	-	348	WP_001555786.1	DUF1493 family protein	-
LUY22_RS05070 (1035065)	1035065..1035514	-	450	WP_023225038.1	hypothetical protein	-
LUY22_RS05075 (1035946)	1035946..1036389	-	444	WP_023225039.1	SPI-1 type III secretion system invasion lipoprotein InvH	-
LUY22_RS05080 (1036847)	1036847..1037497	+	651	WP_072203970.1	type III secretion system transcriptional activator InvF	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	IScluster/Tn	-	-	1032359..1033893	1534

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Vibrio phage ICP1, Orf50 (1-95)

Sequences

Toxin

Protein

• Length: 176 a.a.
• Molecular weight: 19043.87 Da
• Isoelectric Point: 9.7032

>T229394 WP_000971653.1 NZ_CP089795:c1033135-1032608 [Salmonella enterica subsp. enterica serovar Kentucky]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRHDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Nucleotide

• Length: 528 bp

>T229394 NZ_CP124463:c8075-7797 [Escherichia coli]
ATGTACGCAATATCATTTGATTTAACCGTTGCAGATACAGAAAAACATCATCCGAAAGGCGTGTCACAGGCTTACAACGA
TATAAGTTCGACCCTTAAAAGGTACGGATTTGAGCGAATCCAGGGAAGCCTGTACACAAATAGCGATGAAAATATGGCAA
ACCTTTTTCAGGCTATGAACGCATTAAAAGCTCTTGAATGGTTCCCAAATTCAGTCAGGGATATCAGAGCATTCAGGATT
GAACAGTGGTCTGACTTCACTTCGTCTATAAAGGGTTGA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10664.50 Da
• Isoelectric Point: 6.3133

>AT229394 WP_000855694.1 NZ_CP089795:c1033422-1033132 [Salmonella enterica subsp. enterica serovar Kentucky]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Nucleotide

• Length: 291 bp

>AT229394 NZ_CP124463:c8369-8079 [Escherichia coli]
ATGAGAACATTAGAAGAAGTAATTGCGGCCCAGTCACCTGAAAGTCAGGCTATTATCAAAGCTATGGCTGATAAGATGAG
GCTGGAAATCGGAGTGAAAACAATGAATACAGTGCAGATTCCAACAGGTACGATTAAGACATTCGGGCTGCTTGGTATTC
CTTACGAGGTAGGAGAGCCAGCCCAGGAACTACCCGATGGTGATATTCTTGTCAACATTATACTGGTTCAGACAGGTGAG
AAAGAGTTGTACAAACTTTCAAAACTATTACAAGATCCTGATGCAGAGTAA

Structures

Toxin

• AlphaFold DB: A0A3G3DUX8

Antitoxin

• AlphaFold DB: A0A3V8SJE7