Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4289788..4290569 Replicon chromosome
Accession NZ_CP089794
Organism Salmonella enterica subsp. enterica serovar Kentucky strain ZTA19/00814

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A3G3E5T9
Locus tag LUY18_RS20805 Protein ID WP_000625911.1
Coordinates 4289788..4290279 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID V7IUD2
Locus tag LUY18_RS20810 Protein ID WP_001271379.1
Coordinates 4290276..4290569 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LUY18_RS20780 (4284924) 4284924..4287362 - 2439 WP_023224120.1 F4 (K88) fimbrial usher FaeD -
LUY18_RS20785 (4287372) 4287372..4287911 - 540 WP_000721295.1 type 1 fimbrial protein -
LUY18_RS20790 (4287946) 4287946..4288236 - 291 WP_000773469.1 PapB/FocB family fimbrial expression transcriptional regulator -
LUY18_RS20795 (4288823) 4288823..4289050 + 228 WP_001112992.1 hypothetical protein -
LUY18_RS20800 (4289325) 4289325..4289573 - 249 Protein_4070 IS481 family transposase -
LUY18_RS20805 (4289788) 4289788..4290279 - 492 WP_000625911.1 GNAT family N-acetyltransferase Toxin
LUY18_RS20810 (4290276) 4290276..4290569 - 294 WP_001271379.1 DUF1778 domain-containing protein Antitoxin
LUY18_RS20815 (4290887) 4290887..4291108 + 222 WP_052939504.1 hypothetical protein -
LUY18_RS20820 (4291374) 4291374..4292249 + 876 WP_023205266.1 AraC family transcriptional regulator -
LUY18_RS20825 (4292246) 4292246..4292533 + 288 WP_072103482.1 transcriptional regulator RtsB -
LUY18_RS20830 (4292526) 4292526..4292708 - 183 WP_072106065.1 ATP-binding cassette domain-containing protein -
LUY18_RS20835 (4292728) 4292728..4292827 + 100 Protein_4077 hypothetical protein -
LUY18_RS20840 (4292875) 4292875..4293069 + 195 WP_223163373.1 hypothetical protein -
LUY18_RS20845 (4293364) 4293364..4294269 - 906 WP_001268192.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - faeI / faeH / faeF / faeE / faeD / faeC 4277665..4292708 15043


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-144)

Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17663.44 Da        Isoelectric Point: 7.2655

>T229388 WP_000625911.1 NZ_CP089794:c4290279-4289788 [Salmonella enterica subsp. enterica serovar Kentucky]
MISSPEPLHAGHILTPFCCGVDSMDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTAPGRFRRNMPDP
IPIVVLGRLAVDKSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFEPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

>T229388 NZ_CP124460:c4905066-4904959 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACAACCTGGCGGCACCGATCCTGGCGGGGATTATTACCGCAGTGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10938.54 Da        Isoelectric Point: 9.8590

>AT229388 WP_001271379.1 NZ_CP089794:c4290569-4290276 [Salmonella enterica subsp. enterica serovar Kentucky]
MSAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT229388 NZ_CP124460:4905114-4905180 [Escherichia coli]
GTTCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G3E5T9

Antitoxin

Source ID Structure
AlphaFold DB V7IUD2

References