Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 4151602..4152245 Replicon chromosome
Accession NZ_CP089794
Organism Salmonella enterica subsp. enterica serovar Kentucky strain ZTA19/00814

Toxin (Protein)


Gene name vagD Uniprot ID B5F3H8
Locus tag LUY18_RS20075 Protein ID WP_000048134.1
Coordinates 4151829..4152245 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID B5F3H9
Locus tag LUY18_RS20070 Protein ID WP_001261294.1
Coordinates 4151602..4151832 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LUY18_RS20060 (4148615) 4148615..4150753 + 2139 WP_000187821.1 anaerobic ribonucleoside-triphosphate reductase -
LUY18_RS20065 (4150970) 4150970..4151434 + 465 WP_001009178.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
LUY18_RS20070 (4151602) 4151602..4151832 + 231 WP_001261294.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LUY18_RS20075 (4151829) 4151829..4152245 + 417 WP_000048134.1 type II toxin-antitoxin system VapC family toxin Toxin
LUY18_RS20080 (4152306) 4152306..4154219 - 1914 WP_001212148.1 BglG family transcription antiterminator -
LUY18_RS20085 (4154236) 4154236..4154976 - 741 WP_000779255.1 KDGP aldolase family protein -
LUY18_RS20090 (4154973) 4154973..4156091 - 1119 WP_023224150.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
LUY18_RS20095 (4156075) 4156075..4157208 - 1134 WP_023224151.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-44)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15135.50 Da        Isoelectric Point: 8.1381

>T229387 WP_000048134.1 NZ_CP089794:4151829-4152245 [Salmonella enterica subsp. enterica serovar Kentucky]
MSKTYMLDTCICSFIMREQPEAVLKRLEQAVLRRHRIVVSAITYAEMRFGCTGKKASPRHAQLVDAFCSRLDAVLAWDRA
AVDATTEIRAVLAAAGTPIGSNDAAIAGHAIASGAILVTNNVREFERVPGLQYEDWVK

Download         Length: 417 bp

>T229387 NZ_CP124460:4056274-4056576 [Escherichia coli]
ATGGCTCAAAAGAAAAATATAAGGAGTTTTCGTGATGCCTGGTTGGCTGATTTTTTTGTCCATTCAACGCCACATCGAAA
GATCCCTGCTGAAATCCATACCACGTTATCACGAAAGTTGGACATCATTAATGCTGCCACTTCTCATCGGGATTTACGCT
CCCCTCCGGGGAACCGATACGAAGAGTTATCCGGGAAATTACAGGAATACTCCTCCATTAGAGTGAATAAACAGTACCGA
CTGATTTTTAAATGGGTTAATGGCAAGGCCGAAGAATTGTTTTTAGACCCACACAACTACTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8878.90 Da        Isoelectric Point: 4.6677

>AT229387 WP_001261294.1 NZ_CP089794:4151602-4151832 [Salmonella enterica subsp. enterica serovar Kentucky]
MRTVSVFKNGNNRAIRLPRDLDFDGVNELEIFREGDTIILRPARPSWGSFRHEEKASPDFLTEREDIISDEGRFEL

Download         Length: 231 bp

>AT229387 NZ_CP124460:4056612-4056953 [Escherichia coli]
ATGAAACAGGCAACAAGAAAACCGACGACACCCGGAGATATTCTTCTCTATGAATATCTGGAACCGCTCGATTTGAAAAT
CAATGAGTTAGCAGAGTTGCTGCATGTTCATCGTAATAGCGTCAGTGCACTGATCAATAACAATCGTAAACTCACCACTG
AGATGGCATTCCGTCTGGCGAAAGTTTTTGATACCACAGTCGATTTTTGGCTAAACCTCCAGGCGGCAGTTGATCTTTGG
GAAGTTGAAAACAACATGCGTACCCAGGAAGAATTGGGACGGATTGAAACAGTGGCTGAATATTTGGCACGCCGTGAAGA
GCGTGCAAAAAAGGTCGCGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2T8L749

Antitoxin

Source ID Structure
AlphaFold DB A0A3V4SIC2

References