Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3418458..3419078 Replicon chromosome
Accession NZ_CP089794
Organism Salmonella enterica subsp. enterica serovar Kentucky strain ZTA19/00814

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag LUY18_RS16715 Protein ID WP_001280991.1
Coordinates 3418860..3419078 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag LUY18_RS16710 Protein ID WP_000344807.1
Coordinates 3418458..3418832 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LUY18_RS16700 (3413597) 3413597..3414790 + 1194 WP_001039199.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
LUY18_RS16705 (3414813) 3414813..3417962 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
LUY18_RS16710 (3418458) 3418458..3418832 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
LUY18_RS16715 (3418860) 3418860..3419078 + 219 WP_001280991.1 HHA domain-containing protein Toxin
LUY18_RS16720 (3419257) 3419257..3419808 + 552 WP_001278793.1 maltose O-acetyltransferase -
LUY18_RS16725 (3419926) 3419926..3420396 + 471 WP_000136183.1 YlaC family protein -
LUY18_RS16730 (3420452) 3420452..3420592 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
LUY18_RS16735 (3420598) 3420598..3420858 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
LUY18_RS16740 (3421083) 3421083..3422633 + 1551 WP_000213145.1 EAL domain-containing protein -
LUY18_RS16750 (3422864) 3422864..3423253 + 390 WP_023224410.1 MGMT family protein -
LUY18_RS16755 (3423286) 3423286..3423855 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T229383 WP_001280991.1 NZ_CP089794:3418860-3419078 [Salmonella enterica subsp. enterica serovar Kentucky]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T229383 NZ_CP124460:3461589-3461876 [Escherichia coli]
ATGCCAATGGAGTTTGAATGGGATGCAAACAAGGCCAAAAGTAATCGGGTGAAACATGGCATCCGCTTTGAAGATGCGGT
GTTAGTGTTTGATGATCCACAACATTTGTCACAGCAAGATCGCATAGAAAACGGTGAGTATCGCTGGCAGACTATCGGCC
TGGTTCACGGTATCGTGGTTATTCTGGTTGCGCATACCATCCGTTTCGAAAGCGGAAATGAAATTATTCGAATCATCAGT
GCACGAAAAGCAGATCGTAAAGAGAGGAGCCGCTATGAGCATGGTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT229383 WP_000344807.1 NZ_CP089794:3418458-3418832 [Salmonella enterica subsp. enterica serovar Kentucky]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT229383 NZ_CP124460:3461863-3462165 [Escherichia coli]
ATGAGCATGGTTAAACATAAACGAGGGACACCCTCTACACTCGATGTGCAGCATGAGGCCGAACTGAAGGCACTGGCGAA
TAAATTCGACGAAGATATTGATTACAGTGATATCCCGCCTTCCAGCGATGAGCAATGGTCTAACGCAGAACGCGGTAAGT
TTTATCGGCCATTGAAAACCCAGGCTTCGGTGCGTATTGATGCTGATGTGATGGAATGGCTGAAGCGACCTGGTAAAGGC
TATCAAACTCGCCTGAACGCAATTTTACGTGAAGCGATGCTGCGCGATCAGAACAAAAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References