Detailed information of TA system TA229383

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Hha-TomB/-
• Location: 3418458..3419078
• Replicon: chromosome
• Accession: NZ_CP089794
• Organism: Salmonella enterica subsp. enterica serovar Kentucky strain ZTA19/00814

Toxin (Protein)

• Gene name: Hha
• Uniprot ID: V1H8E6
• Locus tag: LUY18_RS16715
• Protein ID: WP_001280991.1
• Coordinates: 3418860..3419078 (+)
• Length: 73 a.a.

Antitoxin (Protein)

• Gene name: TomB
• Uniprot ID: V1H4V6
• Locus tag: LUY18_RS16710
• Protein ID: WP_000344807.1
• Coordinates: 3418458..3418832 (+)
• Length: 125 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LUY18_RS16700 (3413597)	3413597..3414790	+	1194	WP_001039199.1	multidrug efflux RND transporter periplasmic adaptor subunit AcrA	-
LUY18_RS16705 (3414813)	3414813..3417962	+	3150	WP_001132508.1	efflux RND transporter permease AcrB	-
LUY18_RS16710 (3418458)	3418458..3418832	+	375	WP_000344807.1	Hha toxicity modulator TomB	Antitoxin
LUY18_RS16715 (3418860)	3418860..3419078	+	219	WP_001280991.1	HHA domain-containing protein	Toxin
LUY18_RS16720 (3419257)	3419257..3419808	+	552	WP_001278793.1	maltose O-acetyltransferase	-
LUY18_RS16725 (3419926)	3419926..3420396	+	471	WP_000136183.1	YlaC family protein	-
LUY18_RS16730 (3420452)	3420452..3420592	-	141	WP_001197749.1	type B 50S ribosomal protein L36	-
LUY18_RS16735 (3420598)	3420598..3420858	-	261	WP_000801415.1	type B 50S ribosomal protein L31	-
LUY18_RS16740 (3421083)	3421083..3422633	+	1551	WP_000213145.1	EAL domain-containing protein	-
LUY18_RS16750 (3422864)	3422864..3423253	+	390	WP_023224410.1	MGMT family protein	-
LUY18_RS16755 (3423286)	3423286..3423855	-	570	WP_000779802.1	YbaY family lipoprotein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Haemolysin expression modulating, HHA (13-69)

Antitoxin

• Biofilm formation regulator YbaJ (1-116)

Sequences

Toxin

Protein

• Length: 73 a.a.
• Molecular weight: 8613.97 Da
• Isoelectric Point: 8.9008

>T229383 WP_001280991.1 NZ_CP089794:3418860-3419078 [Salmonella enterica subsp. enterica serovar Kentucky]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Nucleotide

• Length: 219 bp

>T229383 NZ_CP124460:3461589-3461876 [Escherichia coli]
ATGCCAATGGAGTTTGAATGGGATGCAAACAAGGCCAAAAGTAATCGGGTGAAACATGGCATCCGCTTTGAAGATGCGGT
GTTAGTGTTTGATGATCCACAACATTTGTCACAGCAAGATCGCATAGAAAACGGTGAGTATCGCTGGCAGACTATCGGCC
TGGTTCACGGTATCGTGGTTATTCTGGTTGCGCATACCATCCGTTTCGAAAGCGGAAATGAAATTATTCGAATCATCAGT
GCACGAAAAGCAGATCGTAAAGAGAGGAGCCGCTATGAGCATGGTTAA

Antitoxin

Protein

• Length: 125 a.a.
• Molecular weight: 14453.27 Da
• Isoelectric Point: 5.1444

>AT229383 WP_000344807.1 NZ_CP089794:3418458-3418832 [Salmonella enterica subsp. enterica serovar Kentucky]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Nucleotide

• Length: 375 bp

>AT229383 NZ_CP124460:3461863-3462165 [Escherichia coli]
ATGAGCATGGTTAAACATAAACGAGGGACACCCTCTACACTCGATGTGCAGCATGAGGCCGAACTGAAGGCACTGGCGAA
TAAATTCGACGAAGATATTGATTACAGTGATATCCCGCCTTCCAGCGATGAGCAATGGTCTAACGCAGAACGCGGTAAGT
TTTATCGGCCATTGAAAACCCAGGCTTCGGTGCGTATTGATGCTGATGTGATGGAATGGCTGAAGCGACCTGGTAAAGGC
TATCAAACTCGCCTGAACGCAATTTTACGTGAAGCGATGCTGCGCGATCAGAACAAAAAATAA

Structures

Toxin

• PDB: 4ICG

Antitoxin

• AlphaFold DB: A0A5I5FGI0