Detailed information of TA system TA229382

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): stbDE/ParE-YafN
• Location: 2427480..2428002
• Replicon: chromosome
• Accession: NZ_CP089794
• Organism: Salmonella enterica subsp. enterica serovar Kentucky strain ZTA19/00814

Toxin (Protein)

• Gene name: stbE
• Uniprot ID: V7IL40
• Locus tag: LUY18_RS11840
• Protein ID: WP_000221345.1
• Coordinates: 2427718..2428002 (+)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: stbD
• Uniprot ID: V1H457
• Locus tag: LUY18_RS11835
• Protein ID: WP_000885424.1
• Coordinates: 2427480..2427728 (+)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LUY18_RS11805 (2423006)	2423006..2423914	-	909	WP_052939372.1	LysR family transcriptional regulator	-
LUY18_RS11810 (2424316)	2424316..2424504	+	189	WP_001276021.1	DUF29 family protein	-
LUY18_RS11815 (2424870)	2424870..2425609	+	740	Protein_2314	hypothetical protein	-
LUY18_RS11820 (2425611)	2425611..2426519	-	909	WP_077906523.1	hypothetical protein	-
LUY18_RS11825 (2426792)	2426792..2427123	-	332	Protein_2316	DUF1493 family protein	-
LUY18_RS11830 (2427209)	2427209..2427328	-	120	Protein_2317	type II and III secretion system	-
LUY18_RS11835 (2427480)	2427480..2427728	+	249	WP_000885424.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
LUY18_RS11840 (2427718)	2427718..2428002	+	285	WP_000221345.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LUY18_RS11845 (2428173)	2428173..2428562	+	390	WP_000194089.1	RidA family protein	-
LUY18_RS11850 (2428614)	2428614..2429693	-	1080	WP_023203126.1	S-adenosylmethionine:tRNA ribosyltransferase-isomerase	-
LUY18_RS11855 (2429886)	2429886..2430374	-	489	WP_023223899.1	MarR family winged helix-turn-helix transcriptional regulator	-
LUY18_RS11860 (2430419)	2430419..2431927	+	1509	WP_023223898.1	FAD-dependent oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2420134..2434784	14650

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-84)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11043.79 Da
• Isoelectric Point: 10.6500

>T229382 WP_000221345.1 NZ_CP089794:2427718-2428002 [Salmonella enterica subsp. enterica serovar Kentucky]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKVTRHRS

Nucleotide

• Length: 285 bp

>T229382 NZ_CP124460:3322477-3322827 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9090.32 Da
• Isoelectric Point: 3.9820

>AT229382 WP_000885424.1 NZ_CP089794:2427480-2427728 [Salmonella enterica subsp. enterica serovar Kentucky]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Nucleotide

• Length: 249 bp

>AT229382 NZ_CP124460:3322232-3322483 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAGGCGCAAGTGAGCAACAATCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Structures

Toxin

• AlphaFold DB: A0A5Y2FFA8

Antitoxin

• AlphaFold DB: A0A5I0WPN5