Detailed information of TA system TA022938

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PumAB/upstrm_HI1419-dnstrm_HI1420
• Location: 337553..338201
• Replicon: chromosome
• Accession: NC_010943
• Organism: Stenotrophomonas maltophilia K279a

Toxin (Protein)

• Gene name: PumA
• Uniprot ID: B2FJ07
• Locus tag: SMLT_RS01585
• Protein ID: WP_012478870.1
• Coordinates: 337553..337840 (+)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: PumB
• Uniprot ID: -
• Locus tag: SMLT_RS01590
• Protein ID: WP_012478871.1
• Coordinates: 337899..338201 (+)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SMLT_RS22325	332897..333241	+	345	WP_049886003.1	hypothetical protein	-
SMLT_RS01560	333316..334077	-	762	WP_012478865.1	NYN domain-containing protein	-
SMLT_RS01570	334915..335202	-	288	WP_012478867.1	hypothetical protein	-
SMLT_RS01575	335568..336692	-	1125	WP_012478868.1	hypothetical protein	-
SMLT_RS01580	336720..337319	-	600	WP_012478869.1	hypothetical protein	-
SMLT_RS01585	337553..337840	+	288	WP_012478870.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
SMLT_RS01590	337899..338201	+	303	WP_012478871.1	putative addiction module antidote protein	Antitoxin
SMLT_RS01595	338259..338582	-	324	WP_012478872.1	hypothetical protein	-
SMLT_RS01600	338662..339069	-	408	WP_044569408.1	hypothetical protein	-
SMLT_RS01605	339663..340433	+	771	WP_012478874.1	DUF3011 domain-containing protein	-
SMLT_RS01610	340493..341437	+	945	WP_012478875.1	ankyrin repeat domain-containing protein	-
SMLT_RS01615	341542..342462	+	921	WP_005407709.1	arginase	-
SMLT_RS01620	342623..342760	+	138	WP_005407710.1	entericidin A/B family lipoprotein	-
SMLT_RS01625	342968..343189	+	222	WP_004153772.1	CsbD family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	302956..338201	35245

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Addiction module killer protein, predicted (2-94)

Antitoxin

• Cro/C1-type helix-turn-helix domain (43-95)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 10802.42 Da
• Isoelectric Point: 10.8940

>T22938 WP_012478870.1 NC_010943:337553-337840 [Stenotrophomonas maltophilia K279a]
MKIQRTRQFATWIDALKDVTARARILARIGRLAEGHPGDHRYLGDGISELRIDAGPGYRLYYTQRGRQLLILLVGGDKSS
QQRDIEKAREIARAL

Nucleotide

• Length: 288 bp

>T22938 NC_010943:337553-337840 [Stenotrophomonas maltophilia K279a]
ATGAAGATCCAGCGTACCCGTCAGTTCGCGACATGGATTGACGCTCTCAAGGACGTAACCGCACGCGCTCGCATCCTGGC
CCGTATCGGTCGGCTCGCTGAAGGCCATCCGGGTGATCACCGCTATCTGGGGGACGGTATTTCCGAACTGCGTATCGATG
CAGGGCCGGGCTACCGCCTGTACTACACCCAGCGCGGCAGGCAGTTGCTGATTCTTTTGGTCGGAGGTGACAAAAGCTCA
CAGCAACGCGATATCGAAAAGGCCAGGGAGATTGCACGTGCCCTGTGA

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 10738.32 Da
• Isoelectric Point: 8.0343

>AT22938 WP_012478871.1 NC_010943:337899-338201 [Stenotrophomonas maltophilia K279a]
MATKKKVELKSFDVAEHLRTPEEMAAYLDACIEESDGDSAFIAKALGDIARAQGMSKVARAAGLSRESLYRALSGERSPD
FATILKVTRALGVRLHASAV

Nucleotide

• Length: 303 bp

>AT22938 NC_010943:337899-338201 [Stenotrophomonas maltophilia K279a]
ATGGCCACTAAGAAAAAAGTCGAACTCAAATCATTTGATGTGGCCGAACACCTTCGGACACCCGAAGAAATGGCAGCCTA
TCTCGACGCCTGCATCGAGGAAAGCGACGGCGATTCCGCGTTCATCGCCAAGGCGCTCGGCGACATCGCGCGCGCTCAGG
GTATGAGCAAGGTTGCGCGCGCGGCGGGCCTGTCGCGCGAGAGTCTTTACCGCGCACTGTCCGGCGAACGCAGCCCCGAT
TTCGCCACCATCCTGAAGGTGACCCGTGCCTTGGGTGTGCGCCTGCATGCCAGTGCCGTGTGA

Structures

Toxin

• AlphaFold DB: A0A854E218