Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
| Location | 1032438..1033252 | Replicon | chromosome |
| Accession | NZ_CP089794 | ||
| Organism | Salmonella enterica subsp. enterica serovar Kentucky strain ZTA19/00814 | ||
Toxin (Protein)
| Gene name | TacT3 | Uniprot ID | A0A3G3DUX8 |
| Locus tag | LUY18_RS05035 | Protein ID | WP_000971653.1 |
| Coordinates | 1032438..1032965 (-) | Length | 176 a.a. |
Antitoxin (Protein)
| Gene name | TacA3 | Uniprot ID | M7S6I2 |
| Locus tag | LUY18_RS05040 | Protein ID | WP_000855694.1 |
| Coordinates | 1032962..1033252 (-) | Length | 97 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LUY18_RS05005 (1028812) | 1028812..1029210 | + | 399 | Protein_982 | cytoplasmic protein | - |
| LUY18_RS05010 (1029421) | 1029421..1029639 | + | 219 | Protein_983 | hypothetical protein | - |
| LUY18_RS05015 (1029796) | 1029796..1030464 | + | 669 | WP_000445914.1 | hypothetical protein | - |
| LUY18_RS05020 (1030491) | 1030491..1030985 | + | 495 | WP_000424946.1 | hypothetical protein | - |
| LUY18_RS05025 (1031157) | 1031157..1031813 | - | 657 | WP_023225036.1 | protein-serine/threonine phosphatase | - |
| LUY18_RS05030 (1032163) | 1032163..1032365 | + | 203 | Protein_987 | IS5/IS1182 family transposase | - |
| LUY18_RS05035 (1032438) | 1032438..1032965 | - | 528 | WP_000971653.1 | GNAT family N-acetyltransferase | Toxin |
| LUY18_RS05040 (1032962) | 1032962..1033252 | - | 291 | WP_000855694.1 | DUF1778 domain-containing protein | Antitoxin |
| LUY18_RS05045 (1033523) | 1033523..1033723 | - | 201 | Protein_990 | transposase | - |
| LUY18_RS05050 (1033964) | 1033964..1034290 | + | 327 | WP_000393295.1 | hypothetical protein | - |
| LUY18_RS05055 (1034563) | 1034563..1034910 | - | 348 | WP_001555786.1 | DUF1493 family protein | - |
| LUY18_RS05060 (1034895) | 1034895..1035344 | - | 450 | WP_023225038.1 | hypothetical protein | - |
| LUY18_RS05065 (1035776) | 1035776..1036219 | - | 444 | WP_023225039.1 | SPI-1 type III secretion system invasion lipoprotein InvH | - |
| LUY18_RS05070 (1036677) | 1036677..1037327 | + | 651 | WP_072203970.1 | type III secretion system transcriptional activator InvF | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | invH / invF / invG / invE / invA / invB | 1031157..1042640 | 11483 | |
| - | inside | IScluster/Tn | - | - | 1032189..1033723 | 1534 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 176 a.a. Molecular weight: 19043.87 Da Isoelectric Point: 9.7032
>T229373 WP_000971653.1 NZ_CP089794:c1032965-1032438 [Salmonella enterica subsp. enterica serovar Kentucky]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRHDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRHDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL
Download Length: 528 bp
>T229373 NZ_CP124460:c841080-840829 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGACAAAGGAACGGAAAAGGAC
ATTATTGAGTGA
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGACAAAGGAACGGAAAAGGAC
ATTATTGAGTGA
Antitoxin
Download Length: 97 a.a. Molecular weight: 10664.50 Da Isoelectric Point: 6.3133
>AT229373 WP_000855694.1 NZ_CP089794:c1033252-1032962 [Salmonella enterica subsp. enterica serovar Kentucky]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK
Download Length: 291 bp
>AT229373 NZ_CP124460:c840832-840578 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAGCAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAACCAGAACCCCTGAAACATAACTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCTTCTGGTATACGCGGTTACTGATGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAGCAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAACCAGAACCCCTGAAACATAACTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCTTCTGGTATACGCGGTTACTGATGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3G3DUX8 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3V8SJE7 |