Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 195163..195923 Replicon chromosome
Accession NZ_CP089794
Organism Salmonella enterica subsp. enterica serovar Kentucky strain ZTA19/00814

Toxin (Protein)


Gene name tacT Uniprot ID A0A5H3Y7E3
Locus tag LUY18_RS00920 Protein ID WP_023225088.1
Coordinates 195438..195923 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A3Z2K6C6
Locus tag LUY18_RS00915 Protein ID WP_072106018.1
Coordinates 195163..195450 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LUY18_RS00900 (191591) 191591..192019 + 429 Protein_179 IS3 family transposase -
LUY18_RS00905 (192215) 192215..192985 - 771 WP_000456879.1 DUF3800 domain-containing protein -
LUY18_RS00910 (194012) 194012..195040 + 1029 WP_023196719.1 HNH endonuclease signature motif containing protein -
LUY18_RS00915 (195163) 195163..195450 + 288 WP_072106018.1 DUF1778 domain-containing protein Antitoxin
LUY18_RS00920 (195438) 195438..195923 + 486 WP_023225088.1 GNAT family N-acetyltransferase Toxin
LUY18_RS00925 (196293) 196293..196832 - 540 WP_000047141.1 copper-binding periplasmic metallochaperone CueP -
LUY18_RS00930 (197005) 197005..197217 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
LUY18_RS00935 (197505) 197505..197795 - 291 WP_000455790.1 HTH-type transcriptional regulator -
LUY18_RS00940 (198234) 198234..198944 + 711 WP_000190524.1 DUF3053 domain-containing protein -
LUY18_RS00945 (198994) 198994..199968 - 975 WP_023225087.1 glyoxylate/hydroxypyruvate reductase GhrB -
LUY18_RS00950 (200187) 200187..200849 - 663 WP_000747548.1 OmpA family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - lpfA 192215..206207 13992


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(13-89)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17756.43 Da        Isoelectric Point: 9.0965

>T229370 WP_023225088.1 NZ_CP089794:195438-195923 [Salmonella enterica subsp. enterica serovar Kentucky]
VGHVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHEKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

>T229370 NZ_CP124460:c522789-522687 [Escherichia coli]
GCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10982.66 Da        Isoelectric Point: 4.6811

>AT229370 WP_072106018.1 NZ_CP089794:195163-195450 [Salmonella enterica subsp. enterica serovar Kentucky]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDM

Download         Length: 288 bp

>AT229370 NZ_CP124460:522649-522917 [Escherichia coli]
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCTCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTTAAATATTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H3Y7E3

Antitoxin

Source ID Structure
AlphaFold DB A0A3Z2K6C6

References