229367

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4287067..4287848 Replicon chromosome
Accession NZ_CP089792
Organism Salmonella enterica subsp. enterica serovar Kentucky strain ZTA19/00816

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A3G3E5T9
Locus tag LUY16_RS20790 Protein ID WP_000625911.1
Coordinates 4287067..4287558 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID V7IUD2
Locus tag LUY16_RS20795 Protein ID WP_001271379.1
Coordinates 4287555..4287848 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LUY16_RS20765 (4282203) 4282203..4284641 - 2439 WP_023224120.1 F4 (K88) fimbrial usher FaeD -
LUY16_RS20770 (4284651) 4284651..4285190 - 540 WP_000721295.1 type 1 fimbrial protein -
LUY16_RS20775 (4285225) 4285225..4285515 - 291 WP_000773469.1 PapB/FocB family fimbrial expression transcriptional regulator -
LUY16_RS20780 (4286102) 4286102..4286329 + 228 WP_001112992.1 hypothetical protein -
LUY16_RS20785 (4286604) 4286604..4286852 - 249 Protein_4070 IS481 family transposase -
LUY16_RS20790 (4287067) 4287067..4287558 - 492 WP_000625911.1 GNAT family N-acetyltransferase Toxin
LUY16_RS20795 (4287555) 4287555..4287848 - 294 WP_001271379.1 DUF1778 domain-containing protein Antitoxin
LUY16_RS20800 (4288166) 4288166..4288387 + 222 WP_052939504.1 hypothetical protein -
LUY16_RS20805 (4288653) 4288653..4289527 + 875 Protein_4074 AraC family transcriptional regulator -
LUY16_RS20810 (4289524) 4289524..4289811 + 288 WP_072103482.1 transcriptional regulator RtsB -
LUY16_RS20815 (4289804) 4289804..4289986 - 183 WP_072106065.1 ATP-binding cassette domain-containing protein -
LUY16_RS20820 (4290006) 4290006..4290105 + 100 Protein_4077 hypothetical protein -
LUY16_RS20825 (4290153) 4290153..4290347 + 195 WP_223163373.1 hypothetical protein -
LUY16_RS20830 (4290642) 4290642..4291547 - 906 WP_001268192.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - faeI / faeH / faeF / faeE / faeD / faeC 4274045..4289986 15941


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-144)

Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17663.44 Da        Isoelectric Point: 7.2655

>T229367 WP_000625911.1 NZ_CP089792:c4287558-4287067 [Salmonella enterica subsp. enterica serovar Kentucky]
MISSPEPLHAGHILTPFCCGVDSMDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTAPGRFRRNMPDP
IPIVVLGRLAVDKSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFEPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

>T229367 NZ_CP124456:109672-109806 [Escherichia coli]
ATGACGAAATATACCCTTATCGGGTTGCTTGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACAGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10938.54 Da        Isoelectric Point: 9.8590

>AT229367 WP_001271379.1 NZ_CP089792:c4287848-4287555 [Salmonella enterica subsp. enterica serovar Kentucky]
MSAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT229367 NZ_CP124456:c109627-109567 [Escherichia coli]
TAAAGTGCATCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G3E5T9

Antitoxin

Source ID Structure
AlphaFold DB V7IUD2

References