Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 4148881..4149524 Replicon chromosome
Accession NZ_CP089792
Organism Salmonella enterica subsp. enterica serovar Kentucky strain ZTA19/00816

Toxin (Protein)


Gene name vagD Uniprot ID B5F3H8
Locus tag LUY16_RS20060 Protein ID WP_000048134.1
Coordinates 4149108..4149524 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID B5F3H9
Locus tag LUY16_RS20055 Protein ID WP_001261294.1
Coordinates 4148881..4149111 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LUY16_RS20045 (4145894) 4145894..4148032 + 2139 WP_000187821.1 anaerobic ribonucleoside-triphosphate reductase -
LUY16_RS20050 (4148249) 4148249..4148713 + 465 WP_001009178.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
LUY16_RS20055 (4148881) 4148881..4149111 + 231 WP_001261294.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LUY16_RS20060 (4149108) 4149108..4149524 + 417 WP_000048134.1 type II toxin-antitoxin system VapC family toxin Toxin
LUY16_RS20065 (4149585) 4149585..4151498 - 1914 WP_001212148.1 BglG family transcription antiterminator -
LUY16_RS20070 (4151515) 4151515..4152255 - 741 WP_000779255.1 KDGP aldolase family protein -
LUY16_RS20075 (4152252) 4152252..4153370 - 1119 WP_023224150.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
LUY16_RS20080 (4153354) 4153354..4154487 - 1134 WP_023224151.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-44)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15135.50 Da        Isoelectric Point: 8.1381

>T229366 WP_000048134.1 NZ_CP089792:4149108-4149524 [Salmonella enterica subsp. enterica serovar Kentucky]
MSKTYMLDTCICSFIMREQPEAVLKRLEQAVLRRHRIVVSAITYAEMRFGCTGKKASPRHAQLVDAFCSRLDAVLAWDRA
AVDATTEIRAVLAAAGTPIGSNDAAIAGHAIASGAILVTNNVREFERVPGLQYEDWVK

Download         Length: 417 bp

>T229366 NZ_CP124456:43990-44295 [Escherichia coli]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTACAGAGTGATATTATTGACAC
GCCCGGGCGACGGATGGTGATCCCCCTGGCCAGTGCACGTCTGCTGTCAGATAAAGTCTCCCGTGAACTTTACCCGGTGG
TGCATATCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAAGAAGTG
GCTGATCTCAGCCACCGCGAAAATGACATCAAAAACGCCATTAACCTGATGTTCTGGGGAATATAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8878.90 Da        Isoelectric Point: 4.6677

>AT229366 WP_001261294.1 NZ_CP089792:4148881-4149111 [Salmonella enterica subsp. enterica serovar Kentucky]
MRTVSVFKNGNNRAIRLPRDLDFDGVNELEIFREGDTIILRPARPSWGSFRHEEKASPDFLTEREDIISDEGRFEL

Download         Length: 231 bp

>AT229366 NZ_CP124456:43770-43988 [Escherichia coli]
ATGAAGCAGCGTATTACAGTGACAGTTGACAGCGACAGCTATCAGTTGCTCAAGGCATATGATGTCAATATCTCCGGTCT
GGTAAGCACAACCATGCAGAATGAAGCCCGTCGTCTGCGTGCCGAACGCTGGAAAGCGGAAAATCAGGAAGGGATGGCTG
AGGTCGCCCGGTTTATTGAAATGAACGGCTCTTTTGCTGACGAGAACAGGGACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2T8L749

Antitoxin

Source ID Structure
AlphaFold DB A0A3V4SIC2

References